2,5-Dichloro-4-Nitroaniline
2,5-Dichloro-4-Nitroaniline combines two chlorines and a nitro group on a single ring alongside the amine — a substitution pattern that produces a strongly coloured, chemically stable intermediate used across azo dye, pigment and specialty agrochemical synthesis. The heavy substitution deactivates the ring while leaving a workable diazotisable amine.
Chelora Chemicals supplies this grade to dye and pigment manufacturers and fine chemical plants worldwide, in bags and drums, with a batch COA and GHS safety data sheet on every consignment.
Product identity
- CAS Number
- 6627-34-5
- IUPAC name
- 2,5-Dichloro-4-nitroaniline
- Molecular formula
- C6H4Cl2N2O2
- Molecular weight
- 207.01 g/mol
- EC / EINECS
- 229-591-5
- MDL number
- MFCD00025157
- SMILES
- Nc1cc(Cl)c([N+](=O)[O-])cc1Cl
- HS Code
- 2921 51*
* Confirm the exact HS heading with your customs broker — nitroaniline derivatives sit under a different subheading from the simple anilines, and destination tariffs vary.
What 2,5-Dichloro-4-Nitroaniline is used for
This intermediate carries two chlorines and one nitro group arranged around the ring relative to the amine — chlorine ortho and meta, nitro para. All three substituents are electron-withdrawing, which leaves an amine that is weakly basic and a ring that is substantially deactivated toward further electrophilic chemistry, but that combination also produces a compound with a strong, characteristic yellow to amber colour in its own right.
That combination of properties — chemical stability plus intrinsic colour — is exactly what makes heavily substituted nitroanilines like this one valuable in the dye and pigment industry, either as diazo components for azo chemistry or, in some formulations, used more directly for their own colour contribution.
Naming and isomer care
This substitution pattern is easily confused with the closely related 4,5-dichloro-2-nitroaniline (CAS 6641-64-1), which places the nitro group ortho to the amine rather than para, and the two chlorines meta and para rather than ortho and meta. The two compounds have the same molecular formula and molecular weight but are distinct isomers with different colour and different downstream chemistry. If your specification sheet or supplier reference quotes a CAS number, send it to us directly and we will confirm the identity before quoting — do not rely on the name alone, given how easily these two are transposed in trade literature.
We supply the wider family of chlorinated nitroanilines used in dye and pigment synthesis — see the full intermediate range.
Appearance and handling character
This product typically ships as a light yellow to amber, or occasionally darker, crystalline powder or solid melting in the region of 154–157 °C — a stable solid through ordinary ambient storage and transport. It is poorly soluble in water and more soluble in organic solvents such as acetone and methanol. Like other nitroanilines it is air- and light-sensitive; suppliers commonly recommend storage in a cool, dark place, and prolonged exposure to air can shift the colour and reduce assay.
| Parameter | Typical value |
|---|---|
| Appearance | Light yellow to amber powder / crystal |
| Assay (GC) | 98.0% min |
| Melting range | 154 – 157 °C |
| Moisture | Reported per batch |
| Isomeric impurities | Reported per batch |
| Insolubles / residue | Reported per batch |
Important: the figures above are indicative of commercial grade material and are offered for planning only. The batch certificate of analysis is the governing document. If your process demands a tighter assay, a colour ceiling or a controlled moisture figure, send us the specification and we will quote against it rather than against a generic grade.
| Property | Value |
|---|---|
| Physical state | Crystalline solid at ambient |
| Melting point | ≈ 154 – 157 °C |
| Water solubility | Poor; practically insoluble |
| Organic solubility | Soluble in acetone, methanol; slight turbidity noted by some suppliers |
| Stability | Air and light sensitive; store cool and dark |
| Amine character | Weakly basic; diazotisable |
Physical constants compiled from public reference data for CAS 6627-34-5 and rounded for readability. As with many specialty nitroanilines, published physical data is thinner than for a bulk aniline — treat the batch COA as the specification.
Where our customers put this molecule to work
Heavily substituted nitroanilines like this one are colour-industry and specialty synthesis intermediates rather than bulk commodity chemicals.
Azo dyes & pigments
Diazotised under controlled conditions and coupled onto naphthol or pyrazolone components, this intermediate contributes both to shade depth and to the fastness properties expected of a heavily substituted azo chromophore.
- Diazo component for yellow-amber to orange shades
- Colour ceiling worth specifying at enquiry
- Consistent isomer purity affects shade repeatability
Specialty agrochemical synthesis
The dichloronitroaniline fragment appears in several agrochemical and specialty synthesis routes, where the specific substitution pattern controls the biological activity or reactivity profile of the finished molecule.
- Custom active-ingredient intermediates
- Isomer purity is critical to the finished activity
- See our agrochemical intermediate range
Fine & custom synthesis
A well-defined, heavily substituted building block for research and custom synthesis work where the specific chlorine and nitro placement is required and cannot be substituted with the more common isomer.
- Research and pilot-scale quantities
- Reference-grade material available
- Available in trial and laboratory packs
Reduction chemistry
Controlled reduction of the nitro group gives access to the corresponding phenylenediamine, opening further heterocyclic and pigment chemistry downstream — a route worth discussing with us if it is your planned use.
- Catalyst-poison specification is critical here
- Talk to our technical desk before committing to a route
- Available in reduction-grade purity on request
Analytical & reference standards
A well-characterised compound used as an analytical reference or method-development standard in laboratories studying nitroaniline and chlorinated aromatic amine chemistry.
- Reference and analytical quantities
- Full analytical documentation available
- Small pack sizes from laboratory scale
Contract & scheduled supply
Colour and specialty chemical plants run campaigns rather than continuous single-product output. We hold inventory and release it against your production plan rather than in one shipment.
- Annual contracts with scheduled call-off
- Price held across the contract period
- Second source held in reserve
How we supply this intermediate
Chelora Chemicals is a supplier and sourcing partner, not a manufacturer. We own no dye-intermediate plant — and on a compound whose name is easily confused with a closely related isomer, that independence lets us confirm exactly what a given batch is rather than simply relaying a supplier's own label.
We place your order with whichever qualified producer best matches your assay, your colour requirement, your price point and your delivery window.
We keep a second qualified source on this specialty line. When a plant goes down for maintenance, your campaign switches source rather than stalling.
- Specification read against the CAS first. We confirm you need 6627-34-5 and not the closely related 4,5-dichloro-2-nitroaniline (CAS 6641-64-1) before we quote a price.
- Batch COA shared before dispatch. You approve the assay, colour and impurity profile against your own spec while the material is still in our warehouse.
- Pre-shipment samples for qualification. New account or new source, your laboratory runs a coupling trial before the full quantity ever moves.
- Inert or dark packing on request. Where colour and assay retention matter, we arrange packing that limits air and light exposure.
- Export machinery handled in-house. Hazard classification, UN-approved packing, labelling, freight booking and customs paperwork are ours to manage.
- Consolidation onto one bill of lading. Ship this material alongside other intermediates from our range — one invoice, one shipment, one counterparty.
Packed to protect colour and assay
With an air- and light-sensitive solid, pack format decides what condition the material is in when your operator opens it. Tell us how it will be charged at your end and we will quote accordingly.
Multi-wall bags with liner
Laminated multi-wall bags with a sealed inner liner, palletised and shrink-wrapped. Economical, and the smaller unit means less material exposed once opened.
Fibre & HDPE drums
UN-certified drums with liner — the preferred format for this product on longer sea transits. Far better protection against air ingress than bagged material.
Opaque / lined drums
Where a colour ceiling is critical, we can arrange opaque or UV-blocking liners to reduce light-driven degradation in transit and storage.
Samples & trial packs
Laboratory samples and pilot quantities dispatched by courier so your colour laboratory can run a coupling trial before committing to campaign volume.
Incoterms to suit you
Quoted on the Incoterm your purchasing team works to. Ocean, air and road freight arranged end-to-end with documentation filed before booking.
Campaign despatch
Because fresher is better on this product, we hold contracted quantity and release it against your production calendar rather than landing a year's requirement at once.
Handle this as a fatal-on-contact nitroaromatic
Related and closely substituted dichloronitroanilines in this family commonly carry a severe acute toxicity profile — fatal in contact with skin or if inhaled alongside skin and eye irritation and aquatic toxicity entries. The summary below is orientation only — the safety data sheet supplied with your consignment is the authoritative document and must govern your risk assessment, PPE selection and emergency planning.
Classified hazards
H310Fatal in contact with skin.H330Fatal if inhaled.H315Causes skin irritation.H319Causes serious eye irritation.H373May cause organ damage through prolonged or repeated exposure.H411Toxic to aquatic life with long lasting effects.
Hazard statements reflect the GHS classification commonly published for closely related dichloronitroaniline isomers. Always read the SDS issued with your specific batch, and treat the fatal-on-contact and fatal-if-inhaled entries as the ones that must shape every control you put in place.
Spill & emergency orientation
Plan your response before the pallet arrives, not after a bag splits. The points below are orientation for your emergency planners — sections 4, 5 and 6 of the SDS are the authoritative instructions and must be posted at the point of use.
- Any skin contact is a medical emergency. Remove contaminated clothing immediately, wash thoroughly, and get the casualty to medical attention without delay.
- Any inhalation is a medical emergency. Move the casualty to fresh air immediately and seek medical attention.
- Sweep, do not hose. The material is toxic to aquatic life. Collect spilled solid mechanically into a labelled, closed container; never wash it to a drain.
- Suppress dust without generating more. Use vacuum collection with appropriate filtration, not a broom.
- Have the SDS with the casualty at all times so the treating clinician has the product identity and CAS number in hand immediately.
Storage
- Cool, dry, dark and sealed. Air and light drive oxidation that costs assay and shifts colour.
- Access-controlled storage. Given the fatal-on-contact classification, restricting who can reach the store is a control measure, not an administrative nicety.
- Segregate from oxidising agents, strong acids and reducing agents not part of a controlled process.
- Bunded storage with a sealed floor. The compound is toxic to aquatic life, and containment matters given the acute severity of skin and inhalation exposure.
- Shelf life is typically 12–24 months in sealed original packing. Re-assay before use after long storage.
Handling & PPE
- Design exposure out entirely — do not manage it down. With a fatal-on-contact and fatal-if-inhaled classification, closed transfer and mechanical charging are the baseline, not a refinement.
- Full-coverage, chemical-resistant skin protection at every point of contact.
- Respiratory protection is mandatory wherever dust may be present, per your exposure assessment.
- Eye protection and an accessible, tested eyewash and safety shower at every charging point.
- Health surveillance and exposure records belong in your occupational health programme given the severity of this classification.
Transport
This material moves as regulated cargo. We classify each consignment, apply UN-approved packaging and labelling, and file the dangerous-goods declaration before the booking is made. The applicable UN number, class and packing group are stated on your shipping documents and SDS — ask us for the current DG paperwork when you plan the shipment.
What travels with every consignment
A chemical shipment is only as good as the file that travels with it. Verifying what the source plant sends is precisely the work you are buying from a supplier.
Certificate of Analysis
Batch-specific assay by GC, appearance, colour, melting range and impurity profile — checked against your purchase specification before we release the goods.
Manufacturing date & lot age
For an air-sensitive nitroaromatic this belongs on the same page as the assay. We disclose production date and storage history for the lot we are offering.
GHS Safety Data Sheet
Full 16-section SDS in GHS format covering hazards, exposure controls, handling, storage, spill response, toxicology and disposal — issued in the language your destination requires.
Dangerous Goods Declaration
UN number, hazard class, packing group and IMDG or IATA declaration prepared and filed before the container is booked, with correctly marked and labelled packaging.
Third-party inspection
SGS, Intertek or Bureau Veritas sampling and inspection arranged on request before loading, giving you independent verification of what actually ships.
Retained & pre-shipment samples
Pre-shipment samples carry the same COA as the commercial lot, so what your laboratory qualifies is exactly what arrives. Retention samples held against the batch.
Getting the substitution pattern right matters
The position of the nitro group relative to the two chlorines is the whole difference between this isomer and its closely related sibling. The routes below are the general industrial pattern, not a process disclosure.
Start with the substituted ring
Two chlorines and a nitro group withdraw electron density, leaving a stable, weakly basic amine and a ring resistant to unwanted side reactions.
Diazotise under controlled conditions
Sodium nitrite in acid at low temperature converts the amine to the diazonium salt, typically needing more careful control than on a less deactivated aniline.
Couple, or reduce
The diazonium salt is coupled onto a naphthol or pyrazolone for azo colour chemistry, or the nitro group is separately reduced to open a diamine-based route.
Finish to grade
The crude product is purified to whatever the end market demands — colour target, agro-active specification or reference-grade purity.
Why isomer purity carries through the whole route
Because the substitution pattern determines both colour and reactivity, a mixed isomer feed causes problems that are hard to trace back to their source:
- The closely related 4,5-dichloro-2-nitroaniline isomer reacts differently under both diazotisation and reduction, and a mixed feed gives an inconsistent product distribution.
- Residual moisture affects nitrite dosing consistency in diazotisation and can hurt yield on a hydrogenation route.
- Oxidation products from air and light exposure are the coloured species behind the drift in appearance and carry into whatever the material is used to make.
- Insolubles add filtration load and can show as specks in the finished dye or pigment.
That chain of consequences is the reason we quote against your written specification rather than a generic technical grade, and the reason the batch COA and lot age are both shared for approval before dispatch.
| Compound | Substitution |
|---|---|
| 2,5-Dichloro-4-nitroaniline CAS 6627-34-5 — this product | Cl ortho & meta NO₂ para to amine |
| 4,5-Dichloro-2-nitroaniline CAS 6641-64-1 | NO₂ ortho Cl meta & para to amine |
Same molecular formula and molecular weight, different colour and different downstream chemistry. We supply both — see the full intermediate range — but always send us the CAS number rather than the name alone.
What actually moves the price of this intermediate
This is a specialty intermediate, not a commodity with a screen price. Knowing what drives the quote helps you time a purchase and read whether an offer is realistic.
Narrow producer base
Fewer plants make this specific isomer than make the simpler mono-substituted anilines, so availability can move faster on a single plant's schedule change.
- We hold a second qualified source where available
- Qualify early rather than at the last minute
- Custom synthesis lead times can run longer
Upstream feedstock
The route back to this intermediate runs through chlorinated benzenes and the nitration chain. Movements in benzene, chlorine and nitric acid feed through within a quarter or so.
- Nitration chain sets the floor
- Handling costs reflect the acute hazard profile
- We flag feedstock-driven moves in the quote
Isomer purity tier
Material with a tight limit on the related isomer prices above a general technical grade. Paying for that assurance is worth it when shade consistency matters; not always worth it otherwise.
- Tell us the end use, not just the purity number
- We will say when a tighter spec is unnecessary
- Isomer limit matters most on colour routes
Lot age and freshness
Aged stock on this product is worth less, because colour drift from air exposure is a real quality signal here, not a cosmetic one.
- Ask for the manufacturing date, always
- Check colour on arrival, not at point of use
- Scheduled release beats bulk stockpiling
Freight & DG surcharges
This is regulated cargo with a severe hazard classification, so freight carries a hazardous surcharge and space is tighter than for general cargo.
- Compare on landed cost, not ex-works
- DG space books out ahead of peak season
- We quote FOB, CIF, CFR or DDP as you prefer
Pack format
Cost per kilo falls from 25 kg bags to drums. If your charging system can take a larger unit, the saving over a campaign usually dwarfs the handling change.
- Small bags carry the highest packing cost
- Light-protected packing has a modest premium
- Disposal of packing is a hidden cost at your end
| If your end use is… | Specify |
|---|---|
| Azo dyes & pigments | Colour ceiling, tight isomer limit, low insolubles |
| Specialty agro intermediates | High assay; isomer purity confirmed against target |
| Reduction to diamine | Low catalyst poisons, controlled moisture |
| Analytical / reference use | Highest available purity, full analytical pack |
| Laboratory / R&D | Small pack, light-protected, fast despatch |
Not sure which column you are in? Describe the reaction you are running and our technical desk will recommend the grade — including confirming the exact isomer you need.
Support that goes beyond shipping the drum
What our technical desk will do
- Confirm the exact isomer. Given how easily this compound and the related 2-nitro isomer are confused in trade documentation, we check the CAS number before we quote, every time.
- Match a grade to your reaction. Tell us whether you are coupling or reducing, and we will recommend the specification accordingly.
- Be honest about colour. We will tell you what the colour drift is likely costing you on a colour-sensitive route and what packing prevents it.
- Review your specification before it goes into a contract, so you are not locked into a limit that no plant can consistently hit.
Regulatory & compliance notes
- Severe hazard classification. Given the fatal-on-contact and fatal-if-inhaled entries typical of this family, confirm your site's occupational health obligations before the first delivery.
- Import controls vary by destination. Some jurisdictions apply registration, licensing or end-use declaration requirements to nitroaromatics. We check the destination rules before quoting.
- Chemical inventory listings differ between regions. Confirm your obligations under the applicable inventory regime for your import volume — we will supply the identity data you need for that filing.
- Dangerous goods documentation is prepared by our export desk and filed before booking.
None of the above is legal advice — your own regulatory affairs team owns the final compliance position for your import. What we commit to is giving you accurate product identity data, an honest statement of the hazard classification and complete documentation to work from.
From enquiry to delivered drum
Send the specification
Product name or CAS 6627-34-5, the assay, colour and impurity limits you work to, quantity, pack preference and destination port.
Receive a firm quote
Pricing, lead time, packing, lot age and Incoterm confirmed in writing within 24 hours — our sourcing desk is staffed around the clock.
Qualify and approve
Sample dispatched if you are qualifying a new source. Batch COA and manufacturing date shared for your approval before the material is released.
Ship and track
DG classification filed, freight booked, export documents issued, and the consignment tracked through transit and clearance to your plant.
What buyers ask us about 2,5-Dichloro-4-Nitroaniline
Is this the same as "4,5-dichloro-2-nitroaniline"?
How dangerous is this material?
What purity do you normally supply?
Why does the material darken toward a deeper colour? Is it off-spec?
What is the minimum order quantity?
How long does delivery take?
How should we store it, and what is the shelf life?
Is this a dangerous good? What paperwork comes with it?
- Batch certificate of analysis, with the manufacturing date
- GHS-format safety data sheet
- Dangerous-goods declaration with UN number, class and packing group
- Commercial invoice, packing list and bill of lading or airway bill
- Certificate of origin and any destination-specific forms
Do you supply to my country?
Do you manufacture this yourself?
Can you hold stock against a production plan?
Request pricing on 2,5-Dichloro-4-Nitroaniline
Send your required assay, colour ceiling, quantity, pack format and destination port. Our sourcing desk is available 24 hours a day, 7 days a week, and comes back with pricing, lead time, lot age and packing options — whether that is a single trial bag or a contracted programme for the season.