2-Bromo-4-Fluoro Acetanilide
2-Bromo-4-Fluoro Acetanilide is an acetamide-protected bromofluoroaniline — a single molecule that carries a reactive aryl bromide, a fixed fluorine and a masked amine all on one ring. That combination makes it a favoured entry point for cross-coupling chemistry, pharmaceutical intermediate synthesis and agrochemical building-block work.
Chelora Chemicals supplies this grade to pharma intermediate manufacturers, custom synthesis houses and fine chemical formulators worldwide, in bottles, drums and bulk quantities, with a batch COA and safety data sheet on every consignment.
Product identity
- CAS Number
- 1009-22-9
- IUPAC name
- N-(2-Bromo-4-fluorophenyl)acetamide
- Molecular formula
- C8H7BrFNO
- Molecular weight
- 232.05 g/mol
- EC / EINECS
- 600-141-3
- MDL number
- MFCD00061118
- SMILES
- CC(=O)Nc1ccc(F)cc1Br
- HS Code
- 2924 29*
* Confirm the exact HS heading with your customs broker — classification of substituted acetanilides varies between destination tariffs.
What 2-Bromo-4-Fluoro Acetanilide is used for
2-Bromo-4-Fluoro Acetanilide is the N-acetyl-protected form of 2-bromo-4-fluoroaniline. Acetylating the amine before the ring is further functionalised serves two purposes at once: it removes the free amine's tendency to interfere with metal-catalysed reactions and oxidising conditions, and it moderates the ring's reactivity so that subsequent steps — bromine displacement, cross-coupling, nitration or further halogenation — proceed cleanly and selectively. Once the chemistry around the bromine and fluorine positions is complete, the acetamide is hydrolysed back off to reveal the free aniline.
In practice this molecule is bought as a protected cross-coupling substrate: plants use the aryl bromide as the reactive handle for Suzuki, Negishi or Buchwald–Hartwig chemistry, while the fixed fluorine and the shielded amine ride along unchanged to the next step.
Why the substitution pattern matters
Bromofluoroacetanilide isomers place the halogens in different positions relative to the amide nitrogen, and that geometry decides which downstream chemistry the molecule supports:
- 2-Bromo-4-fluoroacetanilide (CAS 1009-22-9) — this product. Bromine ortho to the acetamide, fluorine para to it; the bromine sits adjacent to the nitrogen, useful where a directing or steric effect from the amide is wanted at the coupling site.
- 4-Bromo-2-fluoroacetanilide (CAS 326-66-9) — the positional isomer, with the bromine para and the fluorine ortho to the acetamide; used where the opposite geometry is required.
- Other haloacetanilides — a wide family of chloro-, bromo- and fluoro-substituted acetanilides exists for the many substitution patterns pharma and agro synthesis calls for.
If your purchase order simply says "bromofluoroacetanilide", quote us the CAS number and we will confirm the correct positional isomer before the order is placed. We source the related haloacetanilide and haloaniline grades as well through our wider halogenated aromatic intermediate range — ask our technical desk for the current list.
Appearance and handling character
Commercial material ships as a white to almost-white powder or crystalline solid melting around 117–120 °C — a stable solid at ambient temperature and through most shipping routes. It is soluble in common organic solvents such as dichloromethane and methanol and has low water solubility. It is classified as harmful by the standard exposure routes and irritating to eyes, skin and the respiratory system — read the safety section below before planning bulk handling.
| Parameter | Typical value |
|---|---|
| Appearance | White to almost white powder / crystal |
| Assay (GC/HPLC) | 97.0–99.0% min |
| Moisture (KF) | 0.5% max |
| Melting range | 116 – 120 °C |
| Related substances | Reported per batch |
| Residue on ignition | Reported per batch |
Important: the figures above are indicative of commercial grade material and reflect the range seen across suppliers of CAS 1009-22-9. The batch certificate of analysis is the governing document. If your process demands a tighter assay or a specific isomer limit, send us your specification and we will quote against it rather than against a generic grade.
| Property | Value |
|---|---|
| Physical state | Crystalline solid at ambient |
| Melting point | ≈ 117 – 120 °C |
| Boiling point | ≈ 338 °C (predicted) |
| Relative density | ≈ 1.62 (predicted) |
| LogP | ≈ 1.5 |
| pKa (predicted) | ≈ 13.2 |
| Water solubility | Low; sparingly soluble |
| Organic solubility | Soluble in dichloromethane, methanol & other common organic solvents |
| Colour | White to almost white |
Physical constants compiled from public reference and supplier specification data for CAS 1009-22-9 and rounded for readability. Predicted values are marked as such; treat them as orientation, not as a specification.
Where our customers put this molecule to work
2-Bromo-4-Fluoro Acetanilide is a general-purpose protected building block rather than a single-outlet one. Demand is spread across pharmaceutical, agrochemical and fine chemical synthesis wherever a bromofluoro-substituted aniline is needed downstream.
Cross-coupling chemistry
The aryl bromide is a ready substrate for Suzuki, Negishi, Stille and Buchwald–Hartwig couplings, letting synthesis teams install aryl, alkenyl, alkynyl or amino groups at that position while the fluorine and the protected amine stay put.
- Suzuki, Negishi & Buchwald–Hartwig substrate
- Amide protecting group shields the amine
- See our cross-coupling intermediate range
Pharmaceutical intermediates
A bromofluoroaniline scaffold with the amine masked as an acetamide is a recurring starting point for heterocycle-forming and drug-substance synthesis, particularly where a halogen-directed coupling step precedes deprotection to the free aniline.
- Deprotects cleanly to 2-bromo-4-fluoroaniline
- Heterocyclic ring construction
- See our pharma intermediate range
Agrochemical intermediates
Halogenated aniline scaffolds of this kind are common precursors in crop-protection active-ingredient synthesis, where the bromine offers a coupling or displacement handle and the fluorine is retained in the finished active.
- Halogenated active-ingredient synthesis
- Fluorine retained through the synthesis route
- See our agrochemical intermediate range
Fine & specialty synthesis
A well-behaved, storage-stable building block for custom cross-coupling, amide deprotection/reprotection sequences and heterocycle synthesis where the specific 2-bromo-4-fluoro substitution pattern is required.
- Custom coupling and functionalisation work
- Stable, crystalline solid — easy to handle and weigh
- Available in trial and laboratory quantities
Analytical & reference standards
High-purity lots are also supplied in small pack sizes as an analytical reference material for laboratories qualifying related haloacetanilide and haloaniline chemistry.
- High-purity, analytically characterised lots
- Small pack sizes from 25 g
- Full analytical data pack on request
Contract & scheduled supply
Pharma and fine chemical process teams commonly want tonnage released against a production plan rather than in one shipment. We hold inventory and release it to your schedule.
- Annual contracts with scheduled call-off
- Price held across the contract period
- Second source held in reserve
How we supply 2-Bromo-4-Fluoro Acetanilide
Chelora Chemicals is a supplier and sourcing partner, not a manufacturer. We own no bromination or fluorination plant — and for a positional-isomer-sensitive intermediate like this one, that independence works in your favour. We are never obliged to push you whatever a captive unit happens to be running that month.
Instead we place your order with whichever qualified producer best matches your assay, your isomer purity, your price point and your delivery window.
We keep a second qualified source on this line. When a plant goes down for maintenance, or a shipping lane is disrupted, your programme switches source rather than stalling.
- Specification read against the CAS first. We confirm you need 1009-22-9 and not the 4-bromo-2-fluoro positional isomer or another haloacetanilide before we quote a price.
- Batch COA shared before dispatch. You approve the assay, moisture and isomer profile against your own spec while the material is still in our warehouse.
- Hazard status stated up front. This material is classified as harmful and irritant, and we say so at enquiry stage — not in the small print of a document pack that arrives with the goods.
- Pre-shipment samples for qualification. New account or new source, your R&D team runs a lab batch before the full quantity ever moves.
- Packing chosen for your climate. A stable, room-temperature-storable solid, but we still plan format and stowage with you for humid or long-transit routings.
- Export machinery handled in-house. Hazard classification, packing, labelling, freight booking and customs paperwork are ours to manage.
- Consolidation onto one bill of lading. Ship this acetanilide alongside other intermediates from our range — one invoice, one shipment, one counterparty.
Packed the way your lab or plant receives it
Pack format drives your landed cost and your handling effort. Tell us how it will be charged at your end and we will quote the format that suits your operation.
Sealed glass or HDPE bottles
Sealed, labelled bottles for laboratory and pilot quantities — the standard format for R&D and process-development orders.
Fibre & HDPE drums with liner
UN-certified drums with an inner liner for commercial-scale orders, keeping the crystalline solid dry and free-flowing through transit.
Bulk drums & multi-drum lots
Larger commercial quantities packed in multiple drums for process-scale pharma and agrochemical buyers running campaign volumes.
Samples & trial packs
Laboratory samples and pilot quantities dispatched by courier so your R&D team can qualify the grade before committing to campaign volume.
Incoterms to suit you
Quoted on the Incoterm your purchasing team works to. Ocean, air and road freight arranged end-to-end with documentation filed before booking.
Campaign despatch
Pharma and agrochemical production runs to campaign. We hold contracted tonnage and release it against your production calendar instead of landing it all at once.
Handle this as a classified irritant
2-Bromo-4-Fluoro Acetanilide is commonly classified as harmful by inhalation, in contact with skin and if swallowed, and irritating to the eyes, respiratory system and skin. It moves as regulated cargo on many trade lanes. The summary below is orientation only — the safety data sheet supplied with your consignment is the authoritative document and should govern your risk assessment, PPE selection and emergency planning.
Commonly referenced hazards
R23/24/25Toxic by inhalation, in contact with skin and if swallowed.R36/37/38Irritating to eyes, respiratory system and skin.UN 2811Transported as a toxic organic solid, n.o.s. on many lanes — class 6.1, packing group III.
The hazard phrases above reflect the legacy EU risk-phrase classification (hazard codes T, Xi) commonly published for CAS 1009-22-9. Modern GHS classifications can differ by supplier and jurisdiction; always read the SDS issued with your specific batch and treat it as the governing document for labelling and controls.
Spill & emergency orientation
Plan your response before a bottle or drum is opened. The points below are orientation for your emergency planners — sections 4, 5 and 6 of the SDS are the authoritative instructions and should be posted at the point of use.
- Sweep, do not hose. Collect spilled solid mechanically into a labelled container; avoid washing it to a drain.
- Suppress dust. Dry sweeping of a fine solid generates an inhalable aerosol — use vacuum collection or dampen carefully in line with the SDS.
- Avoid skin and eye contact. Given the irritation and toxicity classification, remove contaminated clothing immediately and wash the affected skin thoroughly.
- Have the SDS with the casualty. If ingestion, inhalation or significant skin contact occurs, the treating clinician needs the product identity and CAS number in hand.
- Record significant exposures. For a material classified toxic by all three routes, most occupational regimes expect exposure incidents to be logged — a decision for your EHS function.
Storage
- Cool, dry, well-ventilated store, sealed and away from direct sunlight. This material is stable as a solid well above typical ambient temperature, but moisture ingress can still affect assay over time.
- Keep containers tightly closed to protect against moisture pick-up and airborne contamination.
- Segregate from strong oxidisers and strong acids or bases, in line with standard practice for halogenated aromatic amides.
- Access-controlled storage is good practice given the toxic-by-all-routes classification.
- Shelf life is typically 24 months in sealed original packing under these conditions. Re-assay before use after long storage.
Handling & PPE
- Chemical-resistant gloves, safety glasses and a lab coat as a minimum, given the skin and eye irritation classification and toxicity by contact.
- Local exhaust ventilation or a fume hood when weighing, transferring or dissolving the material, particularly where dust may be generated.
- Respiratory protection where dust is likely, per your own exposure assessment — the inhalation toxicity classification applies.
- Wash hands and exposed skin thoroughly after handling, before eating, drinking or smoking.
- Never discharge to drain or watercourse. Collect spills and residues as chemical waste and dispose of them through a licensed waste route.
Transport
This material commonly moves as regulated cargo (UN 2811, class 6.1, packing group III) on many trade lanes. We classify each consignment, apply UN-approved packaging and labelling, and file the dangerous-goods declaration before the booking is made. The applicable UN number, class and packing group are confirmed on your shipping documents and SDS — ask us for the current DG paperwork when you plan the shipment.
What travels with every consignment
A chemical shipment is only as good as the file that travels with it. Verifying what the source plant sends is precisely the work you are buying from a supplier.
Certificate of Analysis
Batch-specific assay by GC or HPLC, moisture by Karl Fischer, appearance, melting range and related-substances/isomer profile — checked against your purchase specification before we release the goods.
Safety Data Sheet
Full 16-section SDS covering hazards, exposure controls, handling, storage, spill response, toxicology and disposal — issued in the language your destination requires.
Dangerous Goods Declaration
UN number, hazard class, packing group and IMDG or IATA declaration prepared and filed before the container is booked, with correctly marked and labelled packaging.
Certificate of Origin
Chamber-attested where required, plus preferential-origin forms where a trade agreement gives your import duty relief at the destination.
Third-party inspection
SGS, Intertek or Bureau Veritas sampling and inspection arranged on request before loading, giving you independent verification of what actually ships.
Retained & pre-shipment samples
Pre-shipment samples carry the same COA as the commercial lot, so what your laboratory qualifies is exactly what arrives. Retention samples held against the batch.
Three handles, one molecule
Almost every route built on this intermediate uses one of three handles: the aryl bromide, the protected amine, or the fixed fluorine. Understanding which one your process leans on explains why the specification matters and which impurity will hurt you. The routes below are the general industrial pattern, not a process disclosure.
Start with the protected ring
2-Bromo-4-Fluoro Acetanilide provides a stable, storable aryl bromide with a shielded amine and a fixed fluorine, ready for selective downstream chemistry.
Handle one — the bromide
Palladium- or nickel-catalysed cross-coupling at the bromine installs aryl, vinyl, alkynyl or amino substituents while the amide and fluorine stay untouched.
Handle two — deprotection
Acid or base hydrolysis of the acetamide reveals the free 2-bromo-4-fluoroaniline (or its coupled derivative) for further amine-based chemistry.
Finish to grade
The crude product is purified by crystallisation, then standardised to whatever the end market demands — isomer purity limit, colour target or pharmaceutical specification.
Why starting-material quality carries through the whole route
The bromide is usually the reactive site, so anything competing with it, or riding along unnoticed, follows the material down the line:
- Positional isomers such as the 4-bromo-2-fluoro pattern couple just as readily and give a structurally similar by-product that is difficult to separate once downstream chemistry is run.
- Residual free aniline (incomplete acetylation) can interfere with metal-catalysed coupling steps that are sensitive to free amines.
- Colour-forming impurities can carry through crystallisation and show up as colour in an otherwise white or pale finished product.
- Moisture is generally well tolerated by this stable crystalline solid, but should still be controlled ahead of strictly anhydrous coupling conditions.
That chain of consequences is the reason we quote against your written specification rather than a generic technical grade, and the reason the batch COA is shared for approval before dispatch rather than sent with the invoice.
| Intermediate | Principal outlet |
|---|---|
| 2-Bromo-4-fluoroacetanilide CAS 1009-22-9 — this product | Cross-coupling synthesis Pharma intermediate synthesis Agrochemical building block |
| 4-Bromo-2-fluoroacetanilide CAS 326-66-9 | Opposite-geometry coupling routes NSAID & bioactive-molecule synthesis |
| 2-Bromo-4-fluoroaniline Deprotected form | Downstream amine-based chemistry |
If your route calls for one of these related haloacetanilides or the deprotected aniline, we source those as well — see our full halogenated aromatic intermediate range. Send the CAS number and we will confirm the correct material before quoting.
What actually moves the price of this intermediate
2-Bromo-4-Fluoro Acetanilide is not a commodity with a screen price. Knowing what drives the quote helps you time a purchase and read whether an offer is realistic.
Pharma & fine chemical demand cycles
Drug-substance campaigns and custom synthesis programmes pull on the same bromofluoroaniline building block at different points in the year, so demand rarely goes flat in the way a single-outlet intermediate does.
- Quote early for campaign tonnage
- Spot buying at peak costs materially more
- Contracted call-off smooths the exposure
Upstream feedstock
The route to this molecule runs through fluoroaniline synthesis, bromination and acetylation chemistry. Movements in bromine, acetic anhydride and fluorinated aniline feedstock costs feed through within a quarter or so.
- Bromine and fluoroaniline pricing set the floor
- Energy cost weighs on purification steps
- We flag feedstock-driven moves in the quote
Isomer & purity requirements
Cross-coupling and pharma buyers often require a tight positional-isomer limit and full analytical characterisation, which adds cost over a technical fine-chemical grade of the same CAS number.
- Grade selection should match your actual end use
- Some markets require extended documentation
- We check destination rules before quoting
Pack format
Cost per kilo falls from small bottles to lined drums to bulk quantities — and larger packs also mean fewer handling movements for a material classified as toxic and irritant.
- Small bottles carry the highest packing cost
- Bulk drums are cheapest per kilo at volume
- Less manual handling means less exposure
Freight & DG surcharges
This is regulated cargo on many lanes (UN 2811), so ocean freight can carry a hazardous surcharge. Destination and Incoterm move landed cost as much as the ex-works price does.
- Compare on landed cost, not ex-works
- DG space books out ahead of peak season
- We quote FOB, CIF, CFR or DDP as you prefer
Source availability
A plant turnaround, a bromination capacity constraint, or a shipping disruption can take supply offline at short notice. Single-sourced buyers feel this hardest.
- We hold a second qualified source on this line
- Qualify the alternate before you need it
- Ask us about dual-source contracts
| If your end use is… | Specify |
|---|---|
| Cross-coupling substrate | High assay, low residual free-aniline, consistent isomer purity |
| Pharma intermediate synthesis | High assay, tight related-substances limit, full analytical pack |
| Agrochemical intermediate synthesis | Consistent assay batch-to-batch; moisture controlled |
| Fine chemical / custom synthesis | Standard technical grade, cost-optimised |
| Laboratory / R&D | Small pack, high purity, full analytical pack |
Not sure which column you are in? Describe the reaction you are running and our technical desk will recommend the grade — including telling you when a cheaper specification would do the job just as well.
Support that goes beyond shipping the drum
What our technical desk will do
- Match a grade to your reaction. Tell us the coupling or synthesis step you are running and we will recommend the specification — and say so plainly when a tighter, costlier grade would add nothing.
- Be straight about the hazard profile. We state the toxic/irritant classification at enquiry stage so your EHS team can plan handling before the label arrives on the drum.
- Advise on handling and storage for your site conditions, and on confirming which positional isomer your process needs before the first shipment moves.
- Review your specification before it goes into a contract, so you are not locked into a limit that no plant can consistently hit.
Regulatory & compliance notes
- Import controls vary by destination. Some jurisdictions apply registration, licensing or end-use declaration requirements to halogenated aniline intermediates. We check the destination rules before quoting, not after you have raised the PO.
- Chemical inventory listings differ between regions. Confirm your obligations under the applicable inventory regime for your import volume — we will supply the identity data you need for that filing.
- Pharmaceutical starting-material documentation (GMP letters, impurity profiles, regulatory support files) can be arranged for validated supply chains — ask at enquiry stage if your programme requires it.
- Downstream end-use restrictions can apply in certain agrochemical or controlled-substance contexts. Your regulatory team should confirm the position for the end use you have in mind.
None of the above is legal advice — your own regulatory affairs team owns the final compliance position for your import and your workplace. What we commit to is giving you accurate product identity data, an honest statement of the hazard classification and complete documentation to work from.
From enquiry to delivered pallet
Send the specification
Product name or CAS 1009-22-9, the assay and isomer limits you work to, quantity, pack preference and destination port.
Receive a firm quote
Pricing, lead time, packing and Incoterm confirmed in writing within 24 hours — our sourcing desk is staffed around the clock.
Qualify and approve
Sample dispatched if you are qualifying a new source. Batch COA shared for your approval before the material is released.
Ship and track
DG classification filed, freight booked, export documents issued, and the consignment tracked through transit and clearance to your plant.
Often bought alongside this grade
Consolidate several intermediates onto one shipment and one invoice. These are the halogenated anilines and acetanilides our pharma, agrochemical and fine chemical customers most often order in the same programme. Each links through to our full product listing — get in touch with the specific CAS number and we will confirm current availability.
What buyers ask us about 2-Bromo-4-Fluoro Acetanilide
Is this material hazardous?
Can I use the 4-bromo-2-fluoro isomer instead?
What purity do you normally supply?
What is the minimum order quantity?
How long does delivery take?
Does the acetamide protecting group survive storage well?
How should we store it, and what is the shelf life?
Is this a dangerous good? What paperwork comes with it?
- Batch certificate of analysis
- Safety data sheet
- Dangerous-goods declaration with UN number, class and packing group where applicable
- Commercial invoice, packing list and bill of lading or airway bill
- Certificate of origin and any destination-specific forms
Do you supply to my country?
Do you manufacture this yourself?
Can you hold stock against a production plan?
Request pricing on 2-Bromo-4-Fluoro Acetanilide
Send your required assay, quantity, pack format and destination port. Our sourcing desk is available 24 hours a day, 7 days a week, and comes back with pricing, lead time and packing options — whether that is a single trial bottle or a contracted drum programme for the year.