2-Hydrazino-4-Methylbenzothiazole
2-Hydrazino-4-methylbenzothiazole pairs a hydrazine (–NH–NH₂) group at the 2-position of the benzothiazole ring with a methyl substituent at the 4-position. That combination gives synthetic chemists a fused heterocyclic hydrazine that condenses readily with aldehydes, ketones and carboxylic-acid derivatives to build hydrazones, thiazolylhydrazides and fused triazole/thiadiazole ring systems.
Chelora Chemicals supplies this intermediate to pharmaceutical, agrochemical and fine chemical manufacturers building heterocyclic actives and dye chemistry from the benzothiazole-hydrazine scaffold, with a batch COA and safety data sheet on every consignment.
Product identity
- CAS Number
- 20174-68-9
- IUPAC name
- (4-Methyl-1,3-benzothiazol-2-yl)hydrazine
- Molecular formula
- C8H9N3S
- Molecular weight
- 179.24 g/mol
- EC / EINECS
- 243-562-4
- MDL number
- MFCD04448793
- SMILES
- CC1=C2C(SC(=NN)N2)=CC=C1
- HS Code
- 2934 20*
* Confirm the exact HS heading with your customs broker — classification of substituted benzothiazoles varies between destination tariffs.
What 2-Hydrazino-4-Methylbenzothiazole is used for
This molecule sits at the intersection of two useful pieces of chemistry: a fused benzothiazole ring system, prized across pharma, dye and corrosion-inhibitor chemistry for its planarity and electron-rich sulfur/nitrogen heteroatoms, and a hydrazine group hung off the 2-position, which is one of the most versatile functional handles in organic synthesis. Condense that hydrazine with an aldehyde or ketone and you get a hydrazone; react it with a carboxylic acid derivative and you get a hydrazide; cyclise either further and you reach fused triazole, thiadiazole or tetrazole ring systems built on the benzothiazole core.
The 4-methyl substituent is not incidental — it is a common structural marker across a family of related benzothiazolylhydrazines, and it shifts both the electronics of the ring and the physical handling properties (melting point, solubility) relative to the unsubstituted parent, 2-hydrazinobenzothiazole. Formulators who need the plain, unsubstituted scaffold, or a differently substituted analogue, should always work from the specific CAS number rather than a generic "hydrazinobenzothiazole" description.
Where this scaffold is put to work
Benzothiazolylhydrazines as a class are established building blocks across several research and manufacturing programmes:
- Heterocyclic pharmaceutical intermediates. The hydrazine group is condensed to build hydrazone and fused-ring pharmacophores explored across a range of therapeutic research programmes.
- Agrochemical intermediate chemistry. Hydrazide and hydrazone derivatives of substituted benzothiazoles feature in the synthesis of several crop-protection candidate structures.
- Analytical & spectrophotometric reagents. The parent scaffold is documented as a reagent in spectrophotometric determination methods, and the hydrazine group's reactivity with carbonyl compounds underpins several colorimetric assay techniques.
- Dye and colourant chemistry. Hydrazone formation from benzothiazolylhydrazines gives coloured, often fluorescent products used in dye and pigment research.
If your purchase order simply says "hydrazinobenzothiazole" or "methylbenzothiazolyl hydrazine", quote us CAS 20174-68-9 and we will confirm the exact substitution pattern before the order is placed. We can also source the unsubstituted parent and other ring-substituted analogues from the same family — see our full product range for the wider benzothiazole and heterocyclic intermediate catalogue.
Appearance and handling character
Commercial material is typically supplied as white to pale beige needle-like crystals. Like most primary hydrazines and hydrazine derivatives, it is sensitive to air and light and should be stored under an inert atmosphere, away from oxidising agents. It is reported soluble in common organic solvents such as dichloromethane, ethyl acetate and methanol; aqueous solubility is limited. Read the safety section below before planning any handling — hydrazine derivatives carry a well-established hazard pattern that should shape your controls from the outset.
| Parameter | Typical value |
|---|---|
| Appearance | White to pale beige needle crystals |
| Assay (HPLC) | 98.0% min |
| Moisture (KF) | 0.5% max |
| Melting range | 162 – 166 °C |
| Related substance limit | 1.0% max |
| Non-volatile residue | Reported per batch |
Important: the figures above are indicative of commercial grade material and are offered for planning only. The batch certificate of analysis is the governing document. If your process demands a tighter assay, a specific related-substance limit, or a controlled colour figure, send us the specification and we will quote against it rather than against a generic grade.
| Property | Value |
|---|---|
| Physical state | Crystalline solid (needles) at ambient |
| Melting point | 163 – 165 °C |
| Boiling point | ≈ 340 °C @ 760 mmHg |
| Flash point | ≈ 160 °C |
| Density | ≈ 1.39 g/cm³ |
| Refractive index | ≈ 1.774 |
| Partition coeff. (log P) | ≈ 2.66 |
| Vapour pressure | ≈ 8.7×10⁻⁵ mmHg @ 25 °C |
| Organic solubility | Soluble in dichloromethane, ethyl acetate, methanol |
Physical constants compiled from public reference data for CAS 20174-68-9 and rounded for readability; several figures (boiling point, flash point, vapour pressure) are literature or predicted values rather than site-measured constants. Treat them as orientation, not as a specification.
Where our customers put this molecule to work
As a hydrazine-functionalised heterocycle, this intermediate is a general building block rather than a single-outlet chemical — its volume spreads across pharmaceutical, agrochemical, analytical and dye research and manufacture.
Pharmaceutical intermediates
The hydrazine group condenses with aldehydes and ketones to build hydrazone pharmacophores, and with carboxylic-acid derivatives to build hydrazides that are cyclised further into fused triazole and thiadiazole ring systems explored across several therapeutic research programmes.
- Hydrazone & hydrazide formation
- Fused heterocycle (triazole/thiadiazole) construction
- See our pharmaceutical intermediate range
Agrochemical intermediate chemistry
Substituted benzothiazolylhydrazines and their hydrazone/hydrazide derivatives feature in the synthesis of several crop-protection candidate structures, where the fused heterocycle contributes to the target compound's binding and stability profile.
- Hydrazone-based candidate synthesis
- Custom route scouting supported
- See our agrochemical intermediate range
Analytical & spectrophotometric reagents
The parent hydrazinobenzothiazole scaffold is documented as a reagent used in spectrophotometric determination methods; the same carbonyl-reactive hydrazine chemistry underlies several colorimetric and fluorescence-based assay techniques explored in research laboratories.
- Colorimetric & fluorescence assay chemistry
- Supplied with full analytical documentation
- Trial quantities from laboratory scale
Dye & colourant chemistry
Condensing the hydrazine with a suitable carbonyl partner gives coloured, often fluorescent hydrazone products, making this scaffold of interest to dye and pigment researchers working with heterocyclic chromophores.
- Hydrazone chromophore synthesis
- Fluorescent compound research
- Batch colour reported on request
Coordination & ligand chemistry
The nitrogen- and sulfur-rich structure makes this scaffold a candidate ligand precursor for coordination chemistry research, where hydrazone-Schiff-base derivatives are used to complex a range of transition metal ions.
- Schiff-base ligand synthesis
- Metal-complex research
- Available in trial and laboratory quantities
Contract & scheduled supply
R&D and pilot-scale programmes generally call off this intermediate against project milestones rather than in bulk. We hold inventory under proper storage conditions and release it to your schedule, from gram-scale reference lots to multi-kilogram runs.
- Scheduled release against project milestones
- Price held across the contract period
- Second source held in reserve
How we supply this intermediate
Chelora Chemicals is a supplier and sourcing partner, not a manufacturer. We own no benzothiazole plant — and for a specification-sensitive heterocyclic intermediate like this one, that independence works in your favour. We are never obliged to push you whatever a captive unit happens to be running that month.
Instead we place your order with whichever qualified producer best matches your assay, your related-substance tolerance, your price point and your delivery window — whether that is a gram-scale reference lot or a multi-kilogram production run.
We keep a second qualified source on this line, so a single plant's maintenance shutdown or a logistics disruption does not stall your synthesis programme.
- Substitution pattern confirmed against the CAS. We verify you need the 4-methyl-substituted hydrazine at 20174-68-9 and not the unsubstituted parent or another ring-substituted analogue before we quote a price.
- Batch COA shared before dispatch. You approve the assay, moisture and related-substance profile against your own spec while the material is still in our warehouse.
- Hazard status stated up front. As a hydrazine derivative, this material carries a meaningful acute-toxicity and irritancy profile, and we say so at enquiry stage — not in the small print of a document pack that arrives with the goods.
- Pre-shipment samples for qualification. New account or new source, your R&D team runs a lab batch before the full quantity ever moves.
- Packing chosen to protect the crystal form. With a melting point around 164 °C and known air/light sensitivity, pack format and inert-gas flushing matter on longer or tropical routings. We plan both with you.
- Export machinery handled in-house. Hazard classification, UN-approved packing, labelling, freight booking and customs paperwork are ours to manage.
- Consolidation onto one bill of lading. Ship this intermediate alongside other heterocyclic building blocks from our range — one invoice, one shipment, one counterparty.
Packed the way your lab or plant receives it
This intermediate moves in everything from a gram-scale reference vial to a multi-kilogram production drum. Tell us your scale and we will quote the format that protects the material and suits your handling.
Samples & laboratory packs
Amber glass vials or foil-lined bottles under inert headspace for laboratory qualification, route scouting and small-scale reference work.
Fibre & HDPE drums with liner
UN-certified drums with an inert, moisture-excluding liner for pilot-scale and early production quantities, protecting against air and light exposure over transit.
Multi-wall bags with liner
Laminated multi-wall bags with an inner liner for larger production runs, palletised and shrink-wrapped for handling in a scaled-up synthesis operation.
Nitrogen-flushed packing
Nitrogen headspace flushing available across all pack sizes, recommended given the air- and light-sensitivity typical of hydrazine derivatives.
Incoterms to suit you
Quoted on the Incoterm your purchasing team works to. Ocean, air and road freight arranged end-to-end with documentation filed before booking.
Milestone-linked despatch
R&D and early-phase manufacturing programmes often call off material against project milestones. We hold contracted quantity and release it against your schedule.
Handle this as a hydrazine derivative
Hydrazinylbenzothiazoles as a class carry a well-documented acute-toxicity and irritancy hazard pattern — the closely related, better-documented parent compound 2-hydrazinobenzothiazole (CAS 615-21-4) is consistently classified this way across multiple published safety data sheets, and the 4-methyl-substituted compound on this page shares the same reactive hydrazine functional group. A dedicated, widely published SDS specific to CAS 20174-68-9 was not located for this page, so the summary below reflects that class-level pattern as a planning baseline. Always request and read the safety data sheet supplied with your own consignment, and let it — not this page — govern your risk assessment, PPE selection and emergency planning.
Typical hazard pattern for this compound class
H301Toxic if swallowed.H315Causes skin irritation.H319Causes serious eye irritation.
Hazard statements above are drawn from the harmonised classification consistently published for the parent compound 2-hydrazinobenzothiazole (CAS 615-21-4), presented here as a reasonable planning baseline for a hydrazine-substituted benzothiazole of this type. They are not a substitute for the batch-specific SDS, which is the document that should shape your controls.
Spill & emergency orientation
Plan your response before the pack arrives, not after a bottle spills. Sections 4, 5 and 6 of the SDS are the authoritative instructions and should be posted at the point of use.
- Sweep or scoop, do not hose. Collect a spilled solid mechanically into a labelled container rather than washing it to a drain.
- Suppress dust. Dry handling of a fine crystalline solid can generate an inhalable aerosol — use vacuum collection or dampen carefully in line with the SDS.
- Assume skin and eye contact is hazardous. Wash any contact area immediately and thoroughly, and remove contaminated clothing without delay.
- Keep away from oxidising agents during clean-up. Hydrazine derivatives can react exothermically with strong oxidisers.
- Have the SDS with the casualty. A treating clinician needs the product identity, CAS number and functional class (hydrazine derivative) in hand.
Storage
- Cool, dry, dark and well-ventilated store, ideally under inert atmosphere — air and light exposure is the main driver of degradation for hydrazine derivatives of this type.
- Keep containers tightly closed. Repeated opening accelerates both moisture pick-up and oxidative colour drift.
- Segregate from oxidising agents, strong acids and aldehydes/ketones you are not intentionally reacting it with — the hydrazine group reacts readily and can do so unintentionally in storage if these are nearby.
- Refrigerated storage is advisable for extended holds, particularly for smaller research-scale packs that may sit on a shelf for months between uses.
- Re-assay before use after long storage, especially if the material has been exposed to light or opened repeatedly.
Handling & PPE
- Work in a fume hood or well-ventilated area. Minimise dust generation and avoid breathing any fine particulate.
- Skin and eye protection as standard. Chemical-resistant gloves, coveralls and eye/face protection for any direct handling, given the documented skin and eye irritation potential.
- Avoid ingestion pathways. No eating, drinking or smoking in the handling area; wash hands thoroughly after any contact.
- Closed transfer for larger quantities. Mechanical charging and closed transfer reduce both operator exposure and product degradation from air contact.
- No specific carcinogenicity classification is associated with this substance in the sources reviewed for this page — but that is a statement about current public data, not a substitute for your own SDS-based risk assessment.
Transport
This material typically moves as regulated cargo consistent with its hydrazine-derived hazard class. We classify each consignment, apply UN-approved packaging and labelling, and file the dangerous-goods declaration before the booking is made. The applicable UN number, class and packing group are stated on your shipping documents and SDS — ask us for the current DG paperwork when you plan the shipment.
What travels with every consignment
A heterocyclic building block is only as useful as the file that travels with it. Verifying what the source plant sends is precisely the work you are buying from a supplier.
Certificate of Analysis
Batch-specific assay by HPLC, moisture by Karl Fischer, appearance, melting range and related-substance profile — checked against your purchase specification before we release the goods.
GHS Safety Data Sheet
Full 16-section SDS in GHS format covering hazards, exposure controls, handling, storage, spill response, toxicology and disposal — issued in the language your destination requires.
Dangerous Goods Declaration
UN number, hazard class, packing group and IMDG or IATA declaration prepared and filed before the container is booked, with correctly marked and labelled packaging.
Analytical spectra pack
NMR, IR and/or LC-MS confirmation of structure available on request, supporting fast qualification for research and pilot-scale customers.
Third-party inspection
SGS, Intertek or Bureau Veritas sampling and inspection arranged on request before loading, giving you independent verification of what actually ships.
Retained & pre-shipment samples
Pre-shipment samples carry the same COA as the commercial lot, so what your laboratory qualifies is exactly what arrives. Retention samples held against the batch.
What the hydrazine group opens up
Nearly everything built from this intermediate runs through the same reactive centre: the terminal –NH₂ of the hydrazine group condensing with a carbonyl partner. Understanding that reaction explains why the specification matters and which impurity will hurt you. The routes below are the general pattern of use, not a process disclosure.
Start with the scaffold
2-Hydrazino-4-methylbenzothiazole provides a fused, electron-rich benzothiazole ring carrying a reactive hydrazine at the 2-position.
Condense to a hydrazone
Reaction with an aldehyde or ketone under mild acid catalysis gives the corresponding hydrazone — the most common first step in downstream synthesis.
Or acylate to a hydrazide
Reaction with a carboxylic acid, acid chloride or ester gives the corresponding hydrazide, a precursor for further cyclisation chemistry.
Cyclise to the target ring system
Hydrazone or hydrazide intermediates are cyclised, oxidised or otherwise elaborated into the fused triazole, thiadiazole or other heterocyclic target the programme requires.
Why hydrazine purity carries through the whole route
The condensation and acylation reactions above are both driven by that one reactive nitrogen. Anything in the feed that competes for it, or that has already reacted with it, follows the material down the line:
- Oxidised or degraded hydrazine has partly lost its reactivity and simply gives lower conversion — it shows up as reduced yield rather than as an easily identified impurity.
- Residual carbonyl contamination picked up during synthesis or storage can pre-react with the hydrazine, generating an unwanted hydrazone by-product before your intended step even begins.
- Isomeric or ring-position impurities from an incompletely selective synthesis can carry through as a related structure in your finished heterocycle, which is difficult to separate later.
- Moisture is generally well tolerated by this chemistry but can slow reaction rates and affect crystallisation behaviour in the downstream step.
That chain of consequences is the reason we quote against your written specification rather than a generic "98% technical" grade, and the reason the batch COA is shared for approval before dispatch rather than sent with the invoice.
| Intermediate | Principal outlet |
|---|---|
| 2-Hydrazino-4-methylbenzothiazole CAS 20174-68-9 — this product | Pharma & agro hydrazone/hydrazide synthesis |
| 2-Hydrazinobenzothiazole Unsubstituted parent, CAS 615-21-4 | Same chemistry, unsubstituted ring |
| Other ring-substituted hydrazinobenzothiazoles Wider intermediate family | Structure-activity relationship research |
If your route calls for the unsubstituted parent or another ring-substituted analogue, we supply those as well — see our full product range and send us the CAS number so we can confirm the correct material before quoting.
What actually moves the price of this intermediate
This is a specialty heterocyclic building block, not a commodity with a screen price. Knowing what drives the quote helps you time a purchase and read whether an offer is realistic.
Project-driven demand
Because this intermediate is consumed by R&D and pilot-scale synthesis programmes rather than continuous large-volume manufacture, order patterns follow project milestones rather than a seasonal or commodity cycle.
- Lead time depends on quantity and current campaign
- Gram-scale packs typically ship fastest
- Contracted call-off smooths a longer programme
Upstream feedstock
The route back to this intermediate runs through 2-mercapto-4-methylbenzothiazole (or a related precursor) and hydrazine hydrate. Movements in hydrazine hydrate pricing in particular feed through to the quote.
- Hydrazine hydrate cost is a real swing factor
- Energy cost weighs on crystallisation and drying
- We flag feedstock-driven moves in the quote
Regulatory & handling cost
The hydrazine-derived hazard profile raises the compliance cost of producing, storing and moving this material relative to a simple, non-reactive heterocycle. That cost sits inside the price.
- Handling obligations vary by jurisdiction
- We check destination rules before quoting
- Inert-gas packing adds real cost at small scale
Pack format & scale
Cost per gram falls sharply from research-scale vials to kilogram-scale drums. Tell us your target scale early so we can quote the most economical pack for that quantity.
- Small research packs carry the highest cost per gram
- Kilogram-scale is materially cheaper per unit
- Ask about scale-up pricing tiers
Freight & DG surcharges
This moves as regulated cargo, so ocean and air freight carry a hazardous-goods surcharge. Destination and Incoterm move landed cost as much as the ex-works price does.
- Compare on landed cost, not ex-works
- Small packs often ship most economically by air/courier
- We quote FOB, CIF, CFR or DDP as you prefer
Source availability
Specialty heterocyclic producers are fewer in number than commodity intermediate manufacturers, so continuity of supply is something we plan for actively rather than assume.
- We hold a second qualified source on this line
- Qualify the alternate before you need it
- Ask us about dual-source contracts
| If your end use is… | Specify |
|---|---|
| Pharmaceutical hydrazone/hydrazide route | High assay, tight related-substance limit, metals reported |
| Agrochemical candidate synthesis | High assay with related-substance and colour limits |
| Analytical / spectrophotometric reagent | High purity, full analytical pack, small pack size |
| Dye & ligand research | Colour ceiling and consistent crystal form |
| Laboratory / R&D trial | Small pack, current COA, spectra on request |
Not sure which column you are in? Describe the reaction you are running and our technical desk will recommend the grade — including telling you when a cheaper specification would do the job just as well.
Support that goes beyond shipping the pack
What our technical desk will do
- Match a grade to your reaction. Tell us the condensation or acylation step you are running and we will recommend the specification — and say so plainly when a tighter, costlier grade would add nothing.
- Be straight about the hazard profile and its limits. We flag the class-typical hazard pattern at enquiry stage, and are equally clear about which data points are class-level estimates rather than substance-specific measurements.
- Advise on handling and storage for your site conditions — a research-scale bench store is a different problem from a pilot-plant warehouse, and we plan both with you.
- Review your specification before it goes into a contract, so you are not locked into a related-substance limit that no plant can consistently hit.
Regulatory & compliance notes
- Hydrazine-handling obligations are jurisdiction-specific. Several regimes apply exposure monitoring or record-keeping requirements to hydrazine derivatives at certain volumes — confirm what applies at your site before the first delivery.
- Import controls vary by destination. Some jurisdictions apply registration, licensing or end-use declaration requirements to heterocyclic research chemicals. We check the destination rules before quoting, not after you have raised the PO.
- Chemical inventory listings differ between regions. Confirm your obligations under the applicable inventory regime for your import volume — we will supply the identity data you need for that filing.
- Downstream end-use restrictions can apply depending on the finished pharmaceutical or agrochemical target. Your regulatory affairs team should confirm the finished-product position for the programme you are running.
None of the above is legal advice — your own regulatory affairs team owns the final compliance position for your import and your workplace. What we commit to is giving you accurate product identity data, an honest statement of the hazard classification (and its basis) and complete documentation to work from.
From enquiry to delivered pack
Send the specification
Product name or CAS 20174-68-9, the assay and related-substance limits you work to, quantity, pack preference and destination.
Receive a firm quote
Pricing, lead time, packing and Incoterm confirmed in writing within 24 hours — our sourcing desk is staffed around the clock.
Qualify and approve
Sample dispatched if you are qualifying a new source. Batch COA and, on request, analytical spectra shared for your approval before the material is released.
Ship and track
DG classification filed, freight booked, export documents issued, and the consignment tracked through transit and clearance to your site.
Often sourced alongside this grade
Programmes working with this scaffold often need a related benzothiazole or hydrazine intermediate too. Browse the full catalogue below and ask our sourcing desk for any specific CAS number — dedicated pages for these sister chemicals are being added, so for now each of the following opens our general product catalogue rather than an individual product page.
What buyers ask us about this intermediate
What is this material typically used to make?
Is this the same as plain 2-hydrazinobenzothiazole?
Is this material classified as hazardous?
What purity do you normally supply?
What is the minimum order quantity?
How long does delivery take?
Why does the crystal darken or the batch show colour drift in storage?
How should we store it, and what is the shelf life?
Is this a dangerous good? What paperwork comes with it?
- Batch certificate of analysis
- GHS-format safety data sheet
- Dangerous-goods declaration with UN number, class and packing group
- Commercial invoice, packing list and bill of lading or airway bill
- Analytical spectra (NMR/IR/LC-MS), on request
Do you supply to my country?
Do you manufacture this yourself?
Can you hold stock against a project plan?
Request pricing on 2-Hydrazino-4-Methylbenzothiazole
Send your required assay, quantity, pack format and destination. Our sourcing desk is available 24 hours a day, 7 days a week, and comes back with pricing, lead time and packing options — whether that is a single gram-scale reference vial or a contracted, multi-kilogram programme for a scale-up campaign.