2,6-Dichloro Fluoro Benzene
2,6-Dichloro Fluoro Benzene — 2,6-DCFB — is a halex (halogen-exchange) building block that places a single fluorine between two chlorines on the ring. It is a niche but well-established intermediate in pharmaceutical and specialty chemical synthesis, wherever a 2,6-dichloro-substituted fluoroarene fragment is the target.
Chelora Chemicals supplies 2,6-DCFB to fine chemical and pharmaceutical intermediate manufacturers worldwide, in drums and container quantities, with a batch COA and GHS safety data sheet on every consignment.
Product identity
- CAS Number
- 2268-05-5
- IUPAC name
- 1,3-Dichloro-2-fluorobenzene
- Molecular formula
- C6H3Cl2F
- Molecular weight
- 164.99 g/mol
- MDL number
- MFCD00010307
- InChIKey
- JORVCRLRRRRLFI-UHFFFAOYSA-N
- SMILES
- FC1=C(Cl)C=CC=C1Cl
- HS Code
- 2903 99*
* Confirm the exact HS heading with your customs broker — classification of polyhalogenated fluorobenzenes varies between destination tariffs.
What 2,6-Dichloro Fluoro Benzene is used for
2,6-Dichloro Fluoro Benzene is a benzene ring carrying one fluorine flanked symmetrically by two chlorines, at the 1-, 2- and 6-positions. That symmetry is the point: the fluorine sits in a fixed, well-defined position relative to both chlorines, which is exactly what a downstream synthesis needs when it has to build off this ring without ambiguity about where each halogen sits.
In practice 2,6-DCFB is a niche but consistently demanded intermediate for pharmaceutical and specialty chemical manufacturers building complex molecules — rather than a high-volume commodity aromatic. It typically reaches customers who already know precisely which downstream step they will run it through.
Why the substitution pattern matters
Halogenated fluorobenzenes are easy to mis-specify if only "dichlorofluorobenzene" appears on a purchase order — several isomers exist with materially different chemistry:
- 2,6-Dichlorofluorobenzene (CAS 2268-05-5) — this product. One fluorine, symmetrically flanked by chlorines at the 2- and 6-positions.
- 2,3-Dichlorofluorobenzene — an asymmetric isomer used in a separate set of pharmaceutical and agrochemical routes.
- 2,4-Dichlorofluorobenzene — a further isomer, and itself a precursor from which 2,6-DCFB can be derived via selective reduction/rearrangement chemistry in some published routes.
If your purchase order simply says "dichlorofluorobenzene", quote us the CAS number and we will confirm the correct isomer before the order is placed. We supply related halogenated benzenes and anilines as well — see our full fluorinated & halogenated aromatic range.
Appearance and handling character
2,6-DCFB ships as a white to light yellow or light orange powder or crystal, with a melting point in the 37–40 °C range — close enough to typical warehouse and ambient shipping temperatures that a drum may arrive as a solid mass in a cool climate and as a soft, part-melted cake in a hot one. Either state is normal for this material; it is not off-spec. It is a flammable solid with a flash point around 60 °C, so ignition sources and static control deserve attention even though it is not classed as acutely toxic. See the safety section below before planning storage or handling.
| Parameter | Typical value |
|---|---|
| Appearance | White to light yellow to light orange powder / crystal |
| Assay (GC) | 98.0% min |
| Melting range | 37 – 40 °C |
| Total isomeric impurities | 1.5% max |
| Moisture | Reported per batch |
| Non-volatile residue | Reported per batch |
Important: the figures above are indicative of commercial grade material and are offered for planning only. The batch certificate of analysis is the governing document. If your process demands a tighter assay or a specific isomer limit, send us the specification and we will quote against it rather than against a generic grade.
| Property | Value |
|---|---|
| Physical state | Low-melting crystalline solid at ambient |
| Melting point | ≈ 37 – 40 °C |
| Boiling point | ≈ 171 °C @ 760 mmHg |
| Flash point | ≈ 60 °C |
| Water solubility | Very low (halogenated aromatic) |
| Organic solubility | Soluble in common aprotic and chlorinated organic solvents |
| Storage recommendation | Cool storage; some suppliers specify refrigerated (0–10 °C) |
| Odour | Faint, characteristic halogenated-aromatic odour |
Physical constants compiled from public reference and supplier specification data for CAS 2268-05-5 and rounded for readability. Treat them as orientation, not as a specification.
Where our customers put this molecule to work
2,6-DCFB is a targeted, lower-volume intermediate rather than a general-purpose aromatic. Demand concentrates in a handful of specialty routes.
Pharmaceutical intermediates
The best-documented industrial use of the 2,6-dichlorofluorophenyl fragment: fine chemical manufacturers use it as a building block for complex molecules in pharmaceutical synthesis, where the fixed fluorine/chlorine geometry is the reason it is chosen over a cheaper, differently substituted ring.
- Building block for complex pharma molecules
- Chosen for its precise halogen geometry
- See our fine chemical intermediate range
Halex (halogen-exchange) chemistry
2,6-DCFB sits inside the broader halex family: chlorinated precursors such as 1,2,6-trichlorobenzene or dichloronitrobenzenes are converted to the fluorinated ring using catalysed fluoride displacement. Understanding this route helps explain typical impurity patterns in commercial material.
- Fluoride-for-chlorine displacement chemistry
- Related to our chloronitrobenzene range
- Residual chloro-isomers are the main impurity class
Agrochemical & specialty synthesis
Related halogenated fluoroarene and fluoroaniline building blocks feed agrochemical active-ingredient chemistry across the industry; 2,6-DCFB is used in niche routes where this precise halogen pattern is the specified starting material.
- Niche agrochemical intermediate applications
- Available for custom route development
- Ask our technical desk if your route fits
Organometallic & cross-coupling chemistry
The carbon–chlorine and carbon–fluorine bonds on this ring are useful handles for metal-halogen exchange, directed metalation and cross-coupling in research and process chemistry, where the symmetric substitution simplifies regiochemistry.
- Directed ortho-metalation chemistry
- Palladium- and nickel-catalysed coupling
- Available in trial and laboratory quantities
Fine & custom synthesis
A well-characterised, symmetrically substituted fluoroarene for custom amide, ether and heterocycle chemistry where the exact halogen positions — not just "dichlorofluoro" — determine whether the molecule is fit for purpose.
- Reaxys / PubChem-referenced identity
- Custom quantities on request
- Available in trial and laboratory quantities
Contract & scheduled supply
Fine chemical and pharmaceutical intermediate campaigns run to a development or production plan, not a calendar month. We hold inventory and release it against your schedule rather than in one shipment.
- Contracted call-off for ongoing programmes
- Price held across the contract period
- Second source held in reserve
How we supply 2,6-Dichloro Fluoro Benzene
Chelora Chemicals is a supplier and sourcing partner, not a manufacturer. We own no halex fluorination plant — and for a lower-volume, isomer-sensitive intermediate like this one, that independence works in your favour. We are never obliged to push you whatever a captive unit happens to be running that month.
Instead we place your order with whichever qualified producer best matches your assay, your isomer tolerance, your price point and your delivery window.
We keep a second qualified source on this line where volumes justify it. When a plant goes down for maintenance, or a monsoon disrupts a road corridor, your programme is not left without an alternative.
- Specification read against the CAS first. We confirm you need 2268-05-5 and not the 2,3- or 2,4-dichlorofluorobenzene isomer before we quote a price.
- Batch COA shared before dispatch. You approve the assay, melting range and impurity profile against your own spec while the material is still in our warehouse.
- Hazard status stated up front. This material is classified as a flammable solid with skin and eye irritation potential, and we say so at enquiry stage — not in the small print of a document pack that arrives with the goods.
- Pre-shipment samples for qualification. New account or new source, your R&D team runs a lab batch before the full quantity ever moves.
- Packing and cold-chain advice for your climate. With a melting point around 37–40 °C, some producers specify refrigerated storage; we help you decide whether that matters for your transit time and route.
- Export machinery handled in-house. Hazard classification, UN-approved packing, labelling, freight booking and customs paperwork are ours to manage.
- Consolidation onto one bill of lading. Ship 2,6-DCFB alongside other intermediates from our range — one invoice, one shipment, one counterparty.
Packed the way your lab or plant receives it
Pack format drives your landed cost and your handling effort — and for a low-melting flammable solid, it also drives how well the material survives transit. Tell us how it will be charged at your end and we will quote the format that suits your operation.
Fibre & HDPE drums
UN-certified drums with liner, the standard format for this class of intermediate. Better protection for a low-melting solid against caking and moisture pick-up than bagged material.
Laminated bags & jerricans
Smaller commercial and pilot-plant quantities packed in laminated bags or UN-approved jerricans, sized for R&D and early-stage process development.
Samples & trial packs
Laboratory samples and pilot quantities dispatched by courier so your R&D team can qualify the grade before committing to campaign volume.
Temperature-controlled transit
Where your destination climate and transit time make it worthwhile, we can arrange cool-chain or refrigerated container transport to keep the material below its melting point throughout.
Incoterms to suit you
Quoted on the Incoterm your purchasing team works to. Ocean, air and road freight arranged end-to-end with documentation filed before booking.
Programme despatch
Development and production campaigns run to a plan, not a calendar. We hold contracted quantity and release it against your programme rather than landing it all at once.
Handle this as a flammable, irritant solid
2,6-Dichloro fluoro benzene is classified as a flammable solid, and causes skin and eye irritation. It does not carry the acute-toxicity or carcinogenicity classifications seen on several of our other intermediates, but the low flash point and the low melting point both deserve real attention in storage and handling. The summary below is orientation only — the safety data sheet supplied with your consignment is the authoritative document and should govern your risk assessment, PPE selection and emergency planning.
Classified hazards
H228Flammable solid.H315Causes skin irritation.H319Causes serious eye irritation.
Hazard statements reflect the harmonised GHS classification commonly published for CAS 2268-05-5. Supplier classifications may differ in detail; always read the SDS issued with your specific batch, and treat the flammability entry as the one that most shapes your storage and handling controls.
Fire, spill & emergency orientation
Plan your response before the drum arrives, not after a bag splits. The points below are orientation for your emergency planners — sections 4, 5 and 6 of the SDS are the authoritative instructions and should be posted at the point of use.
- Ground and bond containers. As a flammable solid, static discharge during transfer is a real ignition risk — ground and bond receiving equipment and keep ignition sources well clear.
- Fight fire with dry agents. Use dry sand, dry chemical or alcohol-resistant foam; avoid a high-pressure water jet that could scatter burning material.
- Suppress dust. Fine powder handling can generate an inhalable aerosol — use vacuum collection or dampen carefully in line with the SDS.
- Treat skin and eye contact promptly. Wash affected skin with plenty of water; rinse eyes cautiously for several minutes and seek medical attention if irritation persists.
- Collect spilled solid mechanically into a labelled container rather than washing it to a drain, consistent with good housekeeping for any halogenated aromatic.
Storage
- Keep away from heat, sparks, open flames and other ignition sources — no smoking in storage or handling areas, consistent with its flammable-solid classification.
- Cool storage recommended. With a melting point of only 37–40 °C, some suppliers specify refrigerated storage (0–10 °C) to keep the material solid and prevent softening or fusing in warm conditions.
- Keep containers tightly closed in a dry, well-ventilated area, away from direct sunlight.
- Segregate from strong oxidising agents and other materials incompatible with a flammable aromatic solid.
- Shelf life is typically 24 months in sealed original packing under recommended storage conditions. Re-assay before use after long storage.
Handling & PPE
- Use explosion-proof electrical, ventilating and lighting equipment where dust or vapour could accumulate, consistent with the flammable-solid classification.
- Skin and eye protection. Chemical-resistant gloves and eye or face protection given the confirmed skin and eye irritation hazard (H315, H319).
- Respiratory protection where dust may be generated — particularly when breaking a caked drum in a hot climate — per your own exposure assessment.
- Wash thoroughly after handling and before eating, drinking or smoking, as standard practice for any halogenated aromatic intermediate.
- Avoid release to the environment where practical, and dispose of waste and spillage as regulated chemical waste rather than to drain.
Transport
2,6-DCFB commonly moves as regulated cargo consistent with a flammable-solid classification. We classify each consignment, apply UN-approved packaging and labelling, and file the dangerous-goods declaration before the booking is made. The applicable UN number, class and packing group are stated on your shipping documents and SDS — ask us for the current DG paperwork when you plan the shipment.
What travels with every consignment
A chemical shipment is only as good as the file that travels with it. Verifying what the source plant sends is precisely the work you are buying from a supplier.
Certificate of Analysis
Batch-specific assay by GC, melting range, appearance and impurity profile — checked against your purchase specification before we release the goods.
GHS Safety Data Sheet
Full 16-section SDS in GHS format covering hazards, exposure controls, handling, storage, spill response, toxicology and disposal — issued in the language your destination requires.
Dangerous Goods Declaration
Flammable-solid classification, UN number, class and packing group prepared and filed before the container is booked, with correctly marked and labelled packaging.
Certificate of Origin
Chamber-attested where required, plus preferential-origin forms where a trade agreement gives your import duty relief at the destination.
Third-party inspection
SGS, Intertek or Bureau Veritas sampling and inspection arranged on request before loading, giving you independent verification of what actually ships.
Retained & pre-shipment samples
Pre-shipment samples carry the same COA as the commercial lot, so what your laboratory qualifies is exactly what arrives. Retention samples held against the batch.
How this fluoroarene is made, and where it goes
2,6-DCFB is a product of halogen-exchange (halex) chemistry — the industrial route used to introduce fluorine onto an aromatic ring that already carries chlorine or nitro leaving groups. The routes below describe the general industrial pattern, not a process disclosure.
Start with a chlorinated precursor
Industrial routes commonly start from 1,2,6-trichlorobenzene or a dichloronitrobenzene isomer that carries a displaceable leaving group ortho or para-activated toward fluoride attack.
Halex fluorination
Potassium or caesium fluoride displaces the activated chlorine or nitro group under catalysis (commonly a Lewis acid such as ZnCl₂ or PCl₅), installing fluorine at the target position.
Purify to isomer
Distillation and crystallisation separate the 2,6-substitution pattern from any co-formed isomers, giving the grade sold on this page.
Finish to grade
The product is dried and standardised to whatever the end market demands — a tighter isomer limit for pharmaceutical routes, or a relaxed technical grade for bulk fine-chemical use.
Why isomer purity carries through the whole route
The halex step and everything built afterward act on a ring with fixed halogen positions. Anything in the feed with a different substitution pattern follows the material down the line:
- Isomeric dichlorofluorobenzenes (2,3- or 2,4-substituted) react in parallel during downstream steps and give structurally different products that are difficult to separate once formed.
- Residual chlorinated precursor that did not fully convert during halex fluorination competes for the same downstream reagents and can show up as an impurity in the final molecule.
- Moisture matters wherever the halogen is later displaced again, such as in a metal-halogen exchange or a further nucleophilic aromatic substitution.
- Heavy residues from the fluorination step concentrate in the still bottoms and reduce the number of passes you get from a distillation train.
That chain of consequences is the reason we quote against your written specification rather than a generic "98% technical" grade, and the reason the batch COA is shared for approval before dispatch rather than sent with the invoice.
| Intermediate | Principal outlet |
|---|---|
| 2,6-Dichlorofluorobenzene CAS 2268-05-5 — this product | Pharmaceutical intermediates Fine chemical synthesis Cross-coupling chemistry |
| 2,3-Dichlorofluorobenzene Related isomer | Separate pharmaceutical & agro routes |
| 2,3-Dichloronitrobenzene CAS 3209-22-1 | Halex precursor family 2,3-Dichloroaniline route |
If your route calls for one of the others, we supply those as well — see our full range of fluorinated & halogenated aromatic intermediates. Send the CAS number and we will confirm the correct material before quoting.
What actually moves the price of this intermediate
2,6-DCFB is a lower-volume, specification-driven intermediate rather than a commodity with a screen price. Knowing what drives the quote helps you time a purchase and read whether an offer is realistic.
Niche, programme-driven demand
Unlike a high-volume aromatic, demand for 2,6-DCFB tracks specific pharmaceutical and fine chemical development programmes rather than a broad seasonal cycle.
- Lead times can move with programme timelines
- Early notice on volume changes helps sourcing
- Contracted call-off smooths supply for ongoing work
Fluorine chemistry cost base
Halex fluorination depends on potassium or caesium fluoride and catalyst systems whose cost is less elastic than ordinary chlorination chemistry, which keeps this class of intermediate priced above simple chlorinated aromatics of similar molecular weight.
- Fluoride reagent cost is a real cost driver
- Catalyst recovery affects producer economics
- We flag feedstock-driven moves in the quote
Isomer separation cost
Halex fluorination can co-produce related isomers, and isolating the symmetric 2,6-pattern by distillation and crystallisation is a direct driver of cost per kilo.
- Tighter isomer limits cost more to hit
- We quote against your actual limit, not a padded one
- Ask about a relaxed-spec grade if it suits your process
Pack format & cold chain
Because the melting point sits close to ambient, some routes benefit from temperature-controlled transit, which is an added cost worth weighing against the risk of arrival as a caked or part-melted solid.
- Drums are the standard commercial pack
- Cool-chain optional for hot-climate destinations
- Melted-and-resolidified material is not off-spec
Freight & DG surcharges
This is commonly regulated cargo given its flammable-solid classification, so ocean freight carries a hazardous surcharge. Destination and Incoterm move landed cost as much as the ex-works price does.
- Compare on landed cost, not ex-works
- DG space books out ahead of peak season
- We quote FOB, CIF, CFR or DDP as you prefer
Source availability
Because volumes are typically smaller than for commodity aromatics, fewer plants run this chemistry at scale. Qualifying a second source in advance protects a development or production programme from a single point of failure.
- We track available halex-capable sources
- Qualify the alternate before you need it
- Ask us about dual-source contracts
| If your end use is… | Specify |
|---|---|
| Pharmaceutical intermediate synthesis | Tight isomer limit; full analytical pack |
| Cross-coupling / organometallic chemistry | Low moisture; metals reported |
| Agrochemical / specialty synthesis | Assay-driven; isomer limit per process |
| Laboratory / R&D | Small pack, high purity, full analytical pack |
Not sure which column you are in? Describe the reaction you are running and our technical desk will recommend the grade — including telling you when a cheaper specification would do the job just as well.
Support that goes beyond shipping the drum
What our technical desk will do
- Match a grade to your reaction. Tell us the step you are running and we will recommend the specification — and say so plainly when a tighter, costlier grade would add nothing.
- Be straight about the hazard profile. We state the flammable-solid classification at enquiry stage so your EHS team can plan storage and ignition-source controls before the first delivery.
- Advise on cold-chain need for your route and climate — a container crossing the tropics is a different problem from a domestic road delivery in a temperate market.
- Review your specification before it goes into a contract, so you are not locked into a limit that no plant can consistently hit.
Regulatory & compliance notes
- Flammable-solid transport rules apply in most jurisdictions once the classification is confirmed on your specific batch. Confirm the exact UN number and packing group on the SDS supplied with your consignment.
- Import controls vary by destination. Some jurisdictions apply registration, licensing or end-use declaration requirements to fluorinated aromatic intermediates, particularly where a pharmaceutical end use is declared. We check the destination rules before quoting.
- Chemical inventory listings differ between regions. Confirm your obligations under the applicable inventory regime for your import volume — we will supply the identity data you need for that filing.
- Pharmaceutical end-use declarations may trigger additional documentation at some borders. Tell us the declared end use at enquiry stage so we can flag anything relevant early.
None of the above is legal advice — your own regulatory affairs team owns the final compliance position for your import and your workplace. What we commit to is giving you accurate product identity data, an honest statement of the hazard classification and complete documentation to work from.
From enquiry to delivered drum
Send the specification
Product name or CAS 2268-05-5, the assay and isomer limits you work to, quantity, pack preference and destination port.
Receive a firm quote
Pricing, lead time, packing and Incoterm confirmed in writing within 24 hours — our sourcing desk is staffed around the clock.
Qualify and approve
Sample dispatched if you are qualifying a new source. Batch COA shared for your approval before the material is released.
Ship and track
DG classification filed, freight booked, export documents issued, and the consignment tracked through transit and clearance to your plant.
Often bought alongside this grade
Consolidate several intermediates onto one shipment and one invoice. These are the fluoroarenes, chloronitrobenzenes and anilines our pharmaceutical, agrochemical and fine chemical customers most often order in the same programme. Every card below opens our full product catalogue, where our sourcing desk will confirm current availability against the CAS number you need.
What buyers ask us about 2,6-Dichloro Fluoro Benzene
What are the hazards I need to plan for?
Can I use the 2,3- or 2,4-isomer instead?
What purity do you normally supply?
What is the minimum order quantity?
How long does delivery take?
The material arrived caked, melted or as a soft mass. Is it off-spec?
Do I need refrigerated storage for this material?
How should we store it, and what is the shelf life?
Is this a dangerous good? What paperwork comes with it?
- Batch certificate of analysis
- GHS-format safety data sheet
- Dangerous-goods declaration with UN number, class and packing group
- Commercial invoice, packing list and bill of lading or airway bill
- Certificate of origin and any destination-specific forms
Do you supply to my country?
Do you manufacture this yourself?
Can you hold stock against a development or production plan?
Request pricing on 2,6-Dichloro Fluoro Benzene
Send your required assay, quantity, pack format and destination port. Our sourcing desk is available 24 hours a day, 7 days a week, and comes back with pricing, lead time and packing options — whether that is a single trial sample or a contracted programme for an ongoing development.