Diisopropyl Isothiocyanato Phenoxybenzene
Known across the trade by its working abbreviation DIPPI, this molecule is a single-purpose aryl isothiocyanate: a 2,6-diisopropylphenyl ring carrying a 4-phenoxy group and a reactive –N=C=S isothiocyanate at the position between the two isopropyl groups. That steric and electronic combination exists for one reason — it is the key building block for diafenthiuron, one of the world's most widely used thiourea acaricide/insecticide actives.
Chelora Chemicals supplies DIPPI to agrochemical formulators and custom synthesis houses that build the thiourea or triazine-thione active from this intermediate, with a batch COA and safety data sheet on every consignment and cold-chain packing built in from the start.
Product identity
- CAS Number
- 80058-93-1
- IUPAC name
- 1,3-Diisopropyl-2-isothiocyanato-5-phenoxybenzene
- Molecular formula
- C19H21NOS
- Molecular weight
- 311.44 g/mol
- Working abbreviation
- DIPPI
- SMILES
- CC(C)c1c(N=C=S)c(C(C)C)cc(Oc2ccccc2)c1
- HS Code
- 2930 90*
* Confirm the exact HS heading with your customs broker — the sulfur-functional organic heading applied to isothiocyanates differs between tariff schedules.
What DIPPI is used for
DIPPI is built from three pieces bolted onto one benzene ring: two bulky isopropyl groups flanking a central position, a reactive isothiocyanate (–N=C=S) group wedged between them, and a phenoxy bridge sitting opposite. The isopropyl groups are not decoration — they sterically shield the isothiocyanate carbon and slow its reaction rate down to something a formulation chemist can control, while the phenoxy group carries through into the finished active's lipophilicity and field performance.
This is a single-outlet, captive intermediate. Almost every gram of DIPPI produced globally is consumed at the next synthetic step: reacted with a diisopropyl-phenoxyaniline-derived amine to build the substituted thiourea, or carried through to the cyclic triazine-thione, that becomes the active ingredient diafenthiuron — a thiourea proacaricide/insecticide widely used against whitefly, mites and other sucking pests in field and horticultural crops.
Why the isothiocyanate group is handled the way it is
An aryl isothiocyanate is a reactive electrophile by design — that is exactly why it is useful as a coupling partner. It reacts readily with primary and secondary amines to form thioureas, and more slowly with alcohols and water to form thiocarbamates and, ultimately, the corresponding amine plus carbonyl sulfide on hydrolysis. That reactivity is the whole point of the molecule, but it also means:
- Moisture is the enemy. Atmospheric humidity slowly hydrolyses the isothiocyanate, eroding assay and generating a hydrolysis by-product. Sealed, inert-gas packing is not optional.
- Cold storage extends shelf life materially. Reaction rates fall steeply with temperature — we and our source plants store and ship DIPPI frozen or refrigerated under inert atmosphere.
- Amine contamination is a real risk. Any trace of the aniline precursor left in the batch will show up as an unreacted amine impurity later in your process; assay and amine-value limits should both be on your specification.
If your enquiry simply asks for "diisopropyl phenoxy phenyl isothiocyanate" or "DIPPI", quote us CAS 80058-93-1 and we will confirm the exact substitution pattern before the order is placed — the plain 2,6-diisopropylphenyl isothiocyanate (without the phenoxy group) is a related but chemically distinct reagent used elsewhere in fine synthesis, and the two are not interchangeable in a diafenthiuron route. For that or any other sulfur-functional intermediate, see our full product range.
Appearance and handling character
DIPPI is typically supplied as a light yellow solid or low-melting waxy mass — commercial batches can arrive as a solid cake, a soft paste, or an oil depending on storage temperature during transit, since the exact melting behaviour is close to ambient and varies with purity. It is soluble in dichloromethane, ethyl acetate and methanol, and is best handled under a dry, inert atmosphere throughout — from the source reactor to your own charging vessel.
| Parameter | Typical value |
|---|---|
| Appearance | Light yellow solid / waxy mass |
| Assay (HPLC) | 97.0% min |
| Residual amine | Reported per batch |
| Moisture (KF) | 0.2% max |
| Colour (APHA) | Reported per batch |
| Non-volatile residue | Reported per batch |
Important: the figures above are indicative of commercial grade material offered for planning only. The batch certificate of analysis is the governing document. If your process demands a tighter assay, a specific amine-value ceiling, or a controlled colour figure, send us your specification and we will source against it.
| Property | Value |
|---|---|
| Physical state | Solid / low-melting waxy mass at ambient |
| Boiling point | ≈ 411 °C @ 760 mmHg (predicted) |
| Density | ≈ 1.04 g/cm³ (predicted) |
| Solubility | Dichloromethane, ethyl acetate, methanol |
| Water reactivity | Slowly hydrolysed by moisture |
| Recommended storage | -20 °C freezer, inert atmosphere |
| Colour | Light yellow |
| Functional group | Aryl isothiocyanate (–N=C=S) |
Properties marked "predicted" are computed estimates commonly published for CAS 80058-93-1 rather than directly measured constants. Treat every figure on this page as orientation, not as a specification — request the current analytical pack before you finalise a process around it.
Where our customers put this molecule to work
DIPPI is a narrow-outlet, high-value intermediate. Its volume is concentrated in agrochemical active manufacture, with a smaller tail in custom synthesis and reference standard work.
Diafenthiuron manufacture
The principal outlet. DIPPI is condensed with the corresponding diisopropyl-phenoxy aniline (or carried through the triazine-thione route) to build diafenthiuron, a thiourea proacaricide/insecticide used against whitefly, mites and other sucking pests.
- Aryl isothiocyanate coupling partner
- Amine-value and moisture are the critical specs
- See our agrochemical intermediate range
Related thiourea & thiocarbamate actives
The same aryl isothiocyanate chemistry that builds diafenthiuron extends to other hindered diaryl and aryl-alkyl thiourea structures explored in crop protection and veterinary chemistry research, where the bulky 2,6-diisopropyl substitution is prized for its steric protection of the reactive centre.
- Custom thiourea condensation
- Triazine-thione ring construction
- Available for custom synthesis programmes
Reference standards & impurity work
DIPPI itself is also tracked as a known process-related impurity of the finished diafenthiuron active, so analytical and QC laboratories request small, high-purity reference quantities to characterise and quantify it in the finished product.
- Analytical reference-standard packs
- Supplied with full analytical documentation
- Trial quantities from laboratory scale
Fine & specialty synthesis
As a well-characterised, sterically hindered aryl isothiocyanate, DIPPI is also of interest to custom synthesis houses building bespoke thiourea, thiosemicarbazide or heterocyclic structures where the bulky, electron-rich aryl group is required.
- Custom thiourea and thiocarbamate formation
- Available in trial and laboratory quantities
- Technical desk supports route scouting
Cold-chain scheduled supply
Because shelf life is temperature-dependent, most DIPPI buyers want tonnage released close to the point of use rather than held in ambient stock for months. We hold inventory frozen and release it to your production schedule.
- Frozen, inert-atmosphere held stock
- Release timed to your batch plan
- Re-assay offered on any extended hold
Contract manufacture support
For formulators running a continuous diafenthiuron campaign, we structure annual contracts against a call-off schedule so the next DIPPI lot lands cold and fresh right when your reactor needs it — not stockpiled and slowly losing assay in a warehouse.
- Annual contracts with scheduled call-off
- Price held across the contract period
- Second source held in reserve
How we supply DIPPI
Chelora Chemicals is a supplier and sourcing partner, not a manufacturer. We own no isothiocyanate plant — and for a moisture-sensitive, narrow-outlet intermediate like this one, that independence matters: we are never obliged to move material that has sat too long in a warehouse, whatever a captive unit happens to have on hand.
Instead we place your order with a qualified producer running fresh production against your delivery window, and we manage the cold chain from their reactor to your dock.
We keep a second qualified source on this line. Isothiocyanate production is a narrower field than general aniline chemistry, so continuity of supply is something we plan for deliberately rather than assume.
- Substitution pattern confirmed against the CAS. We verify you need the phenoxy-substituted isothiocyanate at 80058-93-1 and not a related but distinct reagent before we quote a price.
- Batch COA shared before dispatch. You approve the assay, moisture and residual-amine profile against your own spec while the material is still in our freezer.
- Cold chain built in, not bolted on. Freezer storage, inert-gas packing and refrigerated freight are planned from the moment the order is confirmed.
- Pre-shipment samples for qualification. New account or new source, your R&D team qualifies a lab batch before the full quantity ever moves.
- Hazard profile stated up front. Aryl isothiocyanates are reactive, irritant materials — we say so at enquiry stage, not in the small print of a document pack that arrives with the goods.
- Export machinery handled in-house. Hazard classification, UN-approved packing, refrigerated freight booking and customs paperwork are ours to manage.
- Consolidation where the cold chain allows. Where practical, ship DIPPI alongside other intermediates from our range on one invoice and one shipment.
Packed to protect a moisture-sensitive reagent
Pack format for DIPPI is driven by one thing above all: keeping air and moisture out between our warehouse and your reactor. Tell us your charging method and we will quote the format that protects assay best.
Sealed, gas-flushed drums
Nitrogen-flushed fibre or steel drums with a sealed liner — the default pack for DIPPI, chosen to exclude air and moisture over transit and interim storage.
Cold-chain freight
Refrigerated or frozen transport booked as standard for this product, with temperature logging on request so you can see the cold chain held from our dock to yours.
Samples & trial packs
Cold-shipped laboratory samples and pilot quantities so your R&D and QC teams can qualify assay, moisture and amine-value before committing to campaign volume.
Incoterms to suit you
Quoted on the Incoterm your purchasing team works to, with refrigerated ocean, air and road freight arranged end-to-end and documentation filed before booking.
Nitrogen-blanketed transfer
We advise nitrogen-blanketed transfer at your end too — once a drum is opened, atmospheric moisture starts the same hydrolysis clock that cold storage was holding back.
Campaign despatch
Diafenthiuron production runs to campaign. We hold contracted tonnage frozen and release it against your production calendar instead of landing it all in one shipment.
Handle this as a reactive, irritant chemical
Aryl isothiocyanates as a class are acutely toxic and irritant materials, and the hazard profile below reflects that class-level pattern — the closely related, better-documented analogue 2,6-diisopropylphenyl isothiocyanate (CAS 25343-70-8) carries this classification, and DIPPI shares the same reactive functional group. A dedicated SDS covering CAS 80058-93-1 specifically is not yet widely published, so treat the summary below as orientation only — always request and read the safety data sheet supplied with your own consignment, and let it govern your risk assessment, PPE selection and emergency planning.
Typical hazard pattern for aryl isothiocyanates
H301Toxic if swallowed.H331Toxic if inhaled.H315Causes skin irritation.H319Causes serious eye irritation.H335May cause respiratory irritation.
Hazard statements above are drawn from the harmonised classification commonly published for the closely related aryl isothiocyanate CAS 25343-70-8, presented here as a reasonable planning baseline for a hindered aryl isothiocyanate of this type. They are not a substitute for the batch-specific SDS, which is the document that should shape your controls.
Spill & emergency orientation
Plan your response before the drum arrives, not after it is opened. Sections 4, 5 and 6 of the SDS are the authoritative instructions and should be posted at the point of use.
- Keep the spill dry and cool. Water accelerates hydrolysis of the isothiocyanate, releasing hydrolysis by-products and generating heat — do not hose a spill.
- Ventilate and contain vapours. Isothiocyanate vapour is a respiratory irritant; use local exhaust ventilation and collect the spilled solid or liquid into a sealed, labelled container.
- Assume skin and eye contact is hazardous. Wash any contact area immediately and thoroughly, and remove contaminated clothing without delay.
- Have the SDS with the casualty. A treating clinician needs the product identity, CAS number and functional group in hand.
- Do not reseal a warmed or opened drum "as is". Once air has entered, hydrolysis has started — re-inert and re-assay rather than assuming the remaining material is unchanged.
Storage
- -20 °C freezer, under inert atmosphere, is the recommended storage condition — this is not an optional refinement for this molecule, it is the difference between a usable batch and a hydrolysed one.
- Keep containers sealed at all times. Every time a drum is opened, atmospheric moisture starts consuming assay; minimise the number of times a pack is opened.
- Protect from light and heat. Both accelerate degradation of the isothiocyanate functional group.
- Segregate from amines, alcohols and water-wet materials, which react directly with the isothiocyanate group.
- Re-assay after any extended hold or any temperature excursion before charging it to a batch — do not assume the COA supplied at dispatch still describes the material months later.
Handling & PPE
- Closed transfer wherever practical. Minimising air contact protects both the product and the operator — isothiocyanate vapour is irritating even at low concentration.
- Respiratory protection where the material is weighed, transferred or opened outside a closed system, sized to your own exposure assessment.
- Skin and eye protection as standard. Chemical-resistant gloves, coveralls and eye/face protection for any direct handling.
- Work in a well-ventilated area or fume hood for any operation that opens the container to ambient air.
- No specific carcinogenicity classification is associated with this substance in the sources reviewed for this page — but that is a statement about current public data, not a substitute for your own SDS-based risk assessment.
Transport
DIPPI moves as regulated, temperature-controlled cargo. We classify each consignment, apply UN-approved packaging and labelling, and file the dangerous-goods declaration before the booking is made, alongside the refrigerated logistics the product needs. The applicable UN number, class and packing group are stated on your shipping documents and SDS — ask us for the current DG paperwork when you plan the shipment.
What travels with every consignment
A moisture-sensitive intermediate is only as good as the cold chain and the paperwork that travel with it. Verifying both is precisely the work you are buying from a supplier.
Certificate of Analysis
Batch-specific assay by HPLC, moisture by Karl Fischer, residual-amine value, colour and appearance — checked against your purchase specification before we release the goods.
GHS Safety Data Sheet
Full 16-section SDS in GHS format covering hazards, exposure controls, handling, storage, spill response, toxicology and disposal — issued in the language your destination requires.
Dangerous Goods Declaration
UN number, hazard class, packing group and IMDG or IATA declaration prepared and filed before the container is booked, matched to correctly marked and labelled packaging.
Cold-chain temperature log
Temperature logging across refrigerated transit on request, so you have documented evidence the cold chain held from our warehouse to your goods-in door.
Third-party inspection
SGS, Intertek or Bureau Veritas sampling and inspection arranged on request before loading, giving you independent verification of what actually ships.
Retained & pre-shipment samples
Pre-shipment samples carry the same COA as the commercial lot, shipped cold so what your laboratory qualifies is exactly what arrives. Retention samples held against the batch.
The one door this molecule opens
Unlike a general-purpose aniline, DIPPI is built for a single downstream reaction: amine addition across the isothiocyanate carbon to build a substituted thiourea. Understanding that reaction explains every handling instruction on this page. The route below is the general industrial pattern, not a process disclosure.
Start with the substituted aniline
The synthesis begins with a 2,6-diisopropyl-4-phenoxyaniline precursor, which carries the same substitution pattern that ends up on DIPPI.
Install the isothiocyanate
The amine is converted to the isothiocyanate — commonly via a thiophosgene or dithiocarbamate-based route — giving DIPPI as the isolated, purified intermediate.
Couple to the second amine
DIPPI is reacted with a second, differently substituted amine (or carried through a triazine-thione cyclisation) to build the thiourea backbone of the active.
Finish to active-ingredient grade
The crude thiourea is crystallised, washed and dried, then standardised to the assay and impurity profile the formulated end product requires.
Why DIPPI quality carries through the whole route
Everything downstream of DIPPI acts on that one reactive carbon. Anything in the feed that has already reacted with it, or that competes with your intended amine for it, follows the material down the line:
- Hydrolysed material has already lost the isothiocyanate group to moisture and simply will not react — it shows up as low yield, not as an identifiable impurity in the finished thiourea.
- Residual unreacted amine from the isothiocyanate-forming step can compete with your coupling amine and generate a symmetric by-product thiourea.
- Trace thiophosgene-route by-products can carry sulfur- or chlorine-containing impurities into the batch depending on the synthesis route used by the source plant.
- Colour bodies from oxidative degradation during storage can carry through into the finished active's appearance specification.
That chain of consequences is why we quote against your written specification rather than a generic "97% technical" grade, and why the batch COA is shared for approval before dispatch rather than sent with the invoice.
| Intermediate | Principal outlet |
|---|---|
| DIPPI CAS 80058-93-1 — this product | Diafenthiuron (thiourea acaricide/insecticide) |
| 2,6-Diisopropylphenyl isothiocyanate Related, non-phenoxy reagent | Fine synthesis & custom thiourea building block |
| Substituted phenylurea/thiourea actives Wider intermediate family | Herbicide & insecticide chemistry generally |
If your route calls for a related isothiocyanate or urea/thiourea intermediate, we source across that family too — see our full product range and send us the CAS number so we can confirm the correct material before quoting.
What actually moves the price of this intermediate
DIPPI is a low-volume, high-value specialty intermediate, not a commodity with a screen price. Knowing what drives the quote helps you time a purchase and read whether an offer is realistic.
Single-crop demand cycle
Diafenthiuron demand tracks whitefly and mite pressure across cotton, vegetable and horticultural crop seasons in the major growing regions, so DIPPI orders cluster ahead of those campaigns.
- Quote well ahead of the growing season
- Spot buying at peak season costs more
- Contracted call-off smooths the exposure
Upstream feedstock & reagent cost
The route back to DIPPI runs through the diisopropyl-phenoxyaniline precursor and a sulfur-transfer reagent for the isothiocyanate-forming step; movements in either feed through to the quote.
- Sulfur-transfer reagent cost is a real swing factor
- Cold-chain energy cost weighs on landed price
- We flag feedstock-driven moves in the quote
Narrow producer base
Fewer plants run isothiocyanate chemistry at scale than run general aniline chemistry, so this line is more source-concentrated than a commodity intermediate — a reason dual-sourcing matters more here, not less.
- We hold a second qualified source on this line
- Qualify the alternate before you need it
- Ask us about dual-source contracts
Cold-chain freight cost
Refrigerated freight and gas-flushed packing carry a real cost premium over ambient cargo, and that premium is part of the landed price on every DIPPI shipment.
- Compare on landed cost, not ex-works
- Refrigerated container space books out ahead of peak season
- We quote FOB, CIF, CFR or DDP as you prefer
Handling & compliance cost
The reactive, irritant hazard profile of an aryl isothiocyanate raises the compliance cost of producing, storing and moving this material relative to a simple aromatic amine.
- Handling obligations vary by jurisdiction
- We check destination rules before quoting
- Cold-chain and inert-gas packing add real cost
Shelf-life-driven pricing
Because assay degrades on ambient hold, older stock is genuinely worth less — a below-market DIPPI offer is worth checking against the COA date before you buy it.
- Always ask for the manufacture and COA date
- Re-assay on any material held over 3 months
- We date-stamp every lot we release
| If your end use is… | Specify |
|---|---|
| Diafenthiuron manufacture | High assay, low amine value, moisture the critical parameter |
| Custom thiourea synthesis | High assay; colour and residual solvent reported |
| Analytical / reference standard | High purity, full analytical pack, small pack size |
| Laboratory / R&D trial | Small cold-shipped pack, current COA |
Not sure which column you are in? Describe the reaction you are running and our technical desk will recommend the grade — including telling you when a cheaper, faster-turnaround specification would do the job just as well.
Support that goes beyond shipping the drum
What our technical desk will do
- Match a grade to your reaction. Tell us the coupling step you are running and we will recommend the specification — and say so plainly when a tighter, costlier grade would add nothing.
- Be straight about the hazard profile and its limits. We flag the class-typical hazard pattern at enquiry stage, and are equally clear about which data points are class-level estimates rather than substance-specific measurements.
- Advise on cold-chain handling for your site — a freezer store in a warm climate is a different logistics problem from one in a temperate country, and we plan both with you.
- Review your specification before it goes into a contract, so you are not locked into a moisture or amine-value limit that no plant can consistently hit.
Regulatory & compliance notes
- End-use registration applies to the finished active, not the intermediate, in most jurisdictions — but confirm your own import classification for a diafenthiuron precursor before the first delivery.
- Import controls vary by destination. Some jurisdictions apply registration, licensing or end-use declaration requirements to agrochemical intermediates. We check the destination rules before quoting, not after you have raised the PO.
- Chemical inventory listings differ between regions. Confirm your obligations under the applicable inventory regime for your import volume — we will supply the identity data you need for that filing.
- Isothiocyanate handling obligations at your site are a matter for your own EHS function; we flag the reactive-hazard profile, the programme around it is yours to run.
None of the above is legal advice — your own regulatory affairs team owns the final compliance position for your import and your workplace. What we commit to is giving you accurate product identity data, an honest statement of what is and is not confirmed for this specific substance, and complete documentation to work from.
From enquiry to delivered, still-cold drum
Send the specification
Product name or CAS 80058-93-1, the assay and moisture limits you work to, quantity, pack preference and destination port.
Receive a firm quote
Pricing, lead time, cold-chain packing and Incoterm confirmed in writing within 24 hours — our sourcing desk is staffed around the clock.
Qualify and approve
Cold-shipped sample dispatched if you are qualifying a new source. Batch COA shared for your approval before the material is released.
Ship and track
DG classification filed, refrigerated freight booked, export documents issued, and the consignment temperature-tracked through transit to your plant.
Often sourced alongside this grade
Formulators running a diafenthiuron or wider thiourea/urea agrochemical programme often need several intermediates from the same family. Browse the full catalogue below and ask our sourcing desk for any specific CAS number — dedicated pages for these sister chemicals are being added, so for now each of the following opens our general product catalogue rather than an individual product page.
What buyers ask us about DIPPI
What is DIPPI actually used to make?
Is this the same as 2,6-diisopropylphenyl isothiocyanate?
Why does this material need frozen, inert-gas storage?
What purity do you normally supply?
What is the minimum order quantity?
How long does delivery take?
The material has softened or looks like an oil rather than a solid — is it off-spec?
How should we store it, and what is the shelf life?
Is this a dangerous good? What paperwork comes with it?
- Batch certificate of analysis
- GHS-format safety data sheet
- Dangerous-goods declaration with UN number, class and packing group
- Commercial invoice, packing list and bill of lading or airway bill
- Cold-chain temperature log, on request
Do you supply to my country?
Do you manufacture this yourself?
Can you hold stock against a production plan?
Request pricing on DIPPI
Send your required assay, quantity, pack format and destination port. Our sourcing desk is available 24 hours a day, 7 days a week, and comes back with pricing, lead time and cold-chain packing options — whether that is a single cold-shipped trial pack or a contracted, campaign-scheduled programme for the year.