Para Chloro Ortho Amino Phenol
Para Chloro Ortho Amino Phenol — often shortened to PCOAP or written as 4-chloro-2-aminophenol — carries both an amine and a hydroxyl group on the same chlorinated ring. That dual functionality is the reason it is a long-standing oxidation dye intermediate (listed as C.I. Oxidation Base 18) as well as a building block across heterocyclic and pharmaceutical synthesis.
Chelora Chemicals supplies PCOAP to hair-colourant formulators, dye manufacturers and fine chemical producers worldwide, in drums and bags, with a batch COA and GHS safety data sheet on every consignment.
Product identity
- CAS Number
- 95-85-2
- IUPAC name
- 2-Amino-4-chlorophenol
- Molecular formula
- C6H6ClNO
- Molecular weight
- 143.57 g/mol
- EC / EINECS
- 202-458-9
- MDL number
- MFCD00007694
- Colour Index
- C.I. 76525 (Oxidation Base 18)
- SMILES
- Nc1cc(Cl)ccc1O
Note: this compound carries an IARC Group 2B classification (possibly carcinogenic to humans) in published hazard assessments. See the safety section below and the SDS for your specific batch before handling.
What Para Chloro Ortho Amino Phenol is used for
This compound carries three functional features on one ring: a hydroxyl group, an amine ortho to it, and a chlorine para to the hydroxyl. That combination of an amine and a phenol positioned close together is what makes 2-amino-4-chlorophenol useful as an oxidation base — the class of intermediate used in oxidative hair colourant chemistry, where the amino-phenol couples with other oxidation bases and couplers under peroxide to build the final colour directly on the hair shaft. It is catalogued in the Colour Index as C.I. 76525, Oxidation Base 18.
Beyond hair-colourant chemistry, the same amino-phenol functionality is a useful building block in heterocyclic synthesis — benzoxazole and related ring systems are readily built from an ortho-amino-phenol — and in pharmaceutical intermediate work, most notably as a reference compound related to the chlorzoxazone family.
Naming and identity
This compound is known by several names in trade literature that all refer to the same CAS number: Para Chloro Ortho Amino Phenol, PCOAP, 4-chloro-2-aminophenol, 2-amino-4-chlorophenol, and o-amino-p-chlorophenol. If your specification sheet uses a different name, send us the CAS number (95-85-2) and we will confirm the identity before quoting.
We supply the wider range of amino-phenol and chloroaniline intermediates used in dye and pharmaceutical synthesis — see the full intermediate range.
Appearance and handling character
PCOAP ships as a pale orange to light brown, or white to grey, crystalline solid — the colour varies noticeably between batches and suppliers, which is normal for this class of amino-phenol rather than a sign of impurity. It melts in the region of 136–141 °C and is only sparingly soluble in water. Like other amino-phenols it is genuinely air-sensitive; suppliers commonly recommend storage under inert gas in a cool, dark place, ideally refrigerated, to preserve colour and assay.
| Parameter | Typical value |
|---|---|
| Appearance | White to grey to pale brown powder / crystal |
| Assay (GC/HPLC) | 98.0% min |
| Melting range | 136 – 141 °C |
| Moisture | Reported per batch |
| Related-substance limits | Reported per batch |
| Insolubles / residue | Reported per batch |
Important: the figures above are indicative of commercial grade material and are offered for planning only. The batch certificate of analysis is the governing document. If your process demands a tighter assay, a colour ceiling or a controlled moisture figure, send us the specification and we will quote against it rather than against a generic grade.
| Property | Value |
|---|---|
| Physical state | Crystalline solid at ambient |
| Melting point | ≈ 136 – 141 °C |
| Boiling point | ≈ 186 °C (estimated) |
| Relative density | ≈ 1.20 (estimated) |
| Water solubility | ≈ 2.3 g/L — sparingly soluble |
| pKa | ≈ 9.3 (predicted) |
| Stability | Air sensitive; store cool, dark, ideally refrigerated |
Physical constants compiled from public reference data for CAS 95-85-2 and rounded for readability. Treat them as orientation, not as a specification.
Where our customers put this molecule to work
PCOAP's amino-phenol functionality gives it a specific, well-established role in oxidation colourant chemistry, alongside use as a heterocyclic and pharmaceutical building block.
Oxidative hair colourant chemistry
Catalogued as C.I. Oxidation Base 18, this compound is a primary intermediate (precursor) in oxidative hair dye formulations, where it reacts under peroxide with couplers to build the finished colour directly on the hair shaft.
- Oxidation base for hair colourant formulation
- Cosmetic-grade material available on request
- Regulatory position confirmed before quoting
Heterocyclic ring construction
The ortho relationship between the amine and hydroxyl is exactly what benzoxazole synthesis requires, making this an efficient starting point for that and related heterocyclic ring systems in fine chemical and pharmaceutical synthesis.
- Benzoxazole and related ring chemistry
- Custom synthesis quantities available
- See our fine chemical range
Pharmaceutical intermediates
This compound is documented as a related compound in the chlorzoxazone pharmacopoeial reference literature, and the amino-phenol motif more broadly supports several heterocyclic drug intermediate routes.
- Pharmacopoeial reference compound
- Tight related-substance limits usually apply
- Full analytical documentation available
Dye & pigment chemistry
Beyond its role in oxidation dyes, the amino-phenol structure supports azo and other colourant chemistry where the amine and hydroxyl together offer coupling and complexing options a simple aniline does not.
- Amino-phenol dye and complexing chemistry
- Colour ceiling worth specifying at enquiry
- See also our related aniline range
Research & reference synthesis
A well-documented compound used as an analytical reference standard and in research settings studying amino-phenol chemistry and oxidative coupling mechanisms.
- Reference and analytical quantities
- Small pack sizes from laboratory scale
- Full analytical documentation available
Contract & scheduled supply
Cosmetic and fine chemical plants run formulation campaigns rather than continuous single-product output. We hold inventory and release it against your production plan rather than in one shipment.
- Annual contracts with scheduled call-off
- Price held across the contract period
- Second source held in reserve
How we supply Para Chloro Ortho Amino Phenol
Chelora Chemicals is a supplier and sourcing partner, not a manufacturer. We own no amino-phenol plant — and on a compound used in cosmetic formulation, where regulatory status and colour-batch consistency both matter, that independence lets us route your order to the right source rather than the most convenient one.
We place your order with whichever qualified producer best matches your assay, your colour requirement, your regulatory documentation needs and your delivery window.
We keep a second qualified source on this line. When a plant goes down for maintenance, your campaign switches source rather than stalling.
- Specification read against the CAS first. We confirm you need 95-85-2, whatever trade name your spec sheet uses, before we quote a price.
- Batch COA shared before dispatch. You approve the assay, colour and impurity profile against your own spec while the material is still in our warehouse.
- Hazard status stated up front. This material carries an IARC Group 2B classification, and we say so at enquiry stage — not in the small print of a document pack that arrives with the goods.
- Cosmetic-use regulatory position checked. Where the end use is a hair colourant formulation, we confirm the current regulatory status for your destination before quoting.
- Pre-shipment samples for qualification. New account or new source, your laboratory qualifies the grade before the full quantity ever moves.
- Export machinery handled in-house. Hazard classification, UN-approved packing, labelling, freight booking and customs paperwork are ours to manage.
Packed to protect colour and assay
With an air-sensitive solid best kept refrigerated, pack format and cold-chain planning both matter. Tell us how it will be charged at your end and we will quote accordingly.
Multi-wall bags with liner
Laminated multi-wall bags with a sealed inner liner, palletised and shrink-wrapped. Economical, and the smaller unit means less material exposed once opened.
Fibre & HDPE drums
UN-certified drums with liner — the preferred format for this product on longer sea transits. Far better protection against air ingress than bagged material.
Refrigerated & nitrogen-blanketed transport
Where colour and assay retention are critical for cosmetic formulation, we can arrange refrigerated transport and nitrogen-blanketed drum packing on request.
Samples & trial packs
Laboratory samples and pilot quantities dispatched by courier so your formulation laboratory can qualify the grade before committing to campaign volume.
Incoterms to suit you
Quoted on the Incoterm your purchasing team works to. Ocean, air and road freight arranged end-to-end with documentation filed before booking.
Campaign despatch
Because fresher is better on this product, we hold contracted quantity and release it against your production calendar rather than landing a year's requirement at once.
Handle this as a Group 2B classified amino-phenol
Para Chloro Ortho Amino Phenol is harmful by all three exposure routes and irritating to eyes, skin and the respiratory system. Independently, published hazard assessments include an IARC Group 2B classification (possibly carcinogenic to humans) for this compound. The summary below is orientation only — the safety data sheet supplied with your consignment is the authoritative document and should govern your risk assessment, PPE selection, exposure monitoring and emergency planning.
Classified hazards
H302Harmful if swallowed.H312Harmful in contact with skin.H332Harmful if inhaled.H315Causes skin irritation.H319Causes serious eye irritation.H335May cause respiratory irritation.
Hazard statements reflect the classification commonly published for CAS 95-85-2, based on older risk-phrase data harmonised to GHS. Independently, this compound carries an IARC Group 2B classification in published carcinogenicity assessments. Always read the SDS issued with your specific batch, and treat the IARC classification as a reason for the same disciplined handling you would apply to any suspected carcinogen, regardless of what the acute hazard statements alone might suggest.
Spill & emergency orientation
Plan your response before the pallet arrives, not after a bag splits. The points below are orientation for your emergency planners — sections 4, 5 and 6 of the SDS are the authoritative instructions and should be posted at the point of use.
- Sweep, do not hose. Collect spilled solid mechanically into a labelled, closed container rather than washing it toward a drain.
- Suppress dust. Dry sweeping of a fine solid generates an inhalable aerosol — use vacuum collection or dampen carefully in line with the SDS.
- Avoid prolonged skin contact. Wash any contaminated skin promptly and change contaminated clothing.
- Have the SDS with the casualty if medical attention is needed, so the responder has the product identity and CAS number in hand.
- Dispose as regulated waste through a licensed contractor, in line with your local chemical waste regulations.
Storage
- Cool, dark, sealed storage, ideally refrigerated (2–8 °C), under inert gas where possible. Air and light drive both colour drift and assay loss on this amino-phenol.
- Access-controlled storage. Given the IARC classification, restricting who can reach the store is a sensible control measure.
- Segregate from strong oxidising agents. The published stability data notes incompatibility with strong oxidisers specifically.
- Keep containers tightly closed between uses rather than leaving a drum open across a shift.
- Shelf life is typically 12–18 months under recommended refrigerated storage; materially shorter at ambient temperature.
Handling & PPE
- Design exposure out where practical. Closed transfer and mechanical charging reduce both acute exposure and any long-term concern associated with the IARC classification.
- Gloves, eye protection and dust-appropriate respiratory protection for routine handling — the same posture you would use for any fine, irritating amino-phenol powder.
- Local exhaust ventilation where the material is charged, milled or weighed in bulk.
- Wash hands and exposed skin after handling, before eating, drinking or smoking.
- Health surveillance is worth discussing with your occupational health provider given the IARC Group 2B classification, particularly for regular handlers.
Transport
We classify each consignment according to the applicable transport regulations, apply appropriate packaging and labelling, and file the export documentation before booking. The applicable UN number, class and packing group (where classified as dangerous goods) are stated on your shipping documents and SDS — ask us for the current paperwork when you plan the shipment.
What travels with every consignment
A chemical shipment is only as good as the file that travels with it. Verifying what the source plant sends is precisely the work you are buying from a supplier.
Certificate of Analysis
Batch-specific assay, appearance, colour, melting range and impurity profile — checked against your purchase specification before we release the goods.
Manufacturing date & lot age
For an air-sensitive amino-phenol this belongs on the same page as the assay. We disclose production date and storage history for the lot we are offering.
Safety Data Sheet
Full 16-section SDS covering hazards, exposure controls, handling, storage, spill response and disposal — issued in the language your destination requires.
Certificate of Origin
Chamber-attested where required, plus preferential-origin forms where a trade agreement gives your import duty relief at the destination.
Cosmetic-use documentation
For hair colourant end uses, we can support the identity and purity documentation your formulation dossier requires, subject to your destination's regulatory framework.
Retained & pre-shipment samples
Pre-shipment samples carry the same COA as the commercial lot, so what your laboratory qualifies is exactly what arrives. Retention samples held against the batch.
Two functional groups, one coordinated purpose
It is worth understanding why the amine and hydroxyl sit exactly where they do, because it explains both the oxidation-dye chemistry and the heterocyclic route. The notes below are general background, not a formulation disclosure.
Two groups, ortho to each other
An amine and a hydroxyl sitting next to each other on the ring is the defining feature — it enables both oxidative coupling chemistry and heterocyclic ring closure in ways a simple aniline or phenol cannot.
Oxidation-dye route
Under peroxide, the amino-phenol oxidises and couples with other oxidation bases and couplers to build the final chromophore directly in the hair-colourant formulation.
Heterocyclic route
The same ortho-amino-phenol arrangement condenses with an appropriate carbonyl partner to close a benzoxazole or related ring, a route used across fine chemical and pharmaceutical synthesis.
Finish to grade
The material is purified to whatever the end market demands — colour and purity for cosmetic formulation, or a tight related-substance limit for pharmaceutical synthesis.
Why feed quality carries through the whole route
Because both the amine and the hydroxyl participate in downstream chemistry, impurities that touch either functional group cause problems:
- Oxidation products from air exposure are the same coloured species behind the batch-to-batch colour variation, and they compete with the intended oxidative coupling in a hair-colourant formulation.
- Isomeric amino-chlorophenols would couple or ring-close differently, giving an inconsistent shade or a contaminated heterocyclic product.
- Residual moisture affects handling and weighing accuracy in cosmetic formulation, where dosing precision matters.
- Metal trace impurities can catalyse unwanted oxidation during storage, accelerating the colour drift this material is already prone to.
That chain of consequences is the reason we quote against your written specification rather than a generic grade, and the reason the batch COA and lot age are both shared for approval before dispatch.
| Route | Product & typical use |
|---|---|
| Oxidative coupling | Hair colourant formulation C.I. Oxidation Base 18 |
| Ring closure | Benzoxazole & related heterocycles Pharmaceutical intermediates |
| Direct use | Reference and analytical material Custom synthesis |
We supply the wider range of amino-phenol and chloroaniline intermediates as well — see the full intermediate range.
What actually moves the price of this intermediate
This is a specialty intermediate, not a commodity with a screen price. Knowing what drives the quote helps you time a purchase and read whether an offer is realistic.
Cosmetic formulation cycles
Hair-colourant formulation demand tracks the broader personal-care manufacturing calendar and is generally steadier than a seasonal agrochemical intermediate, but regulatory reviews in any single market can shift demand quickly.
- Watch for regulatory review cycles by destination
- Contracted call-off smooths routine demand
- We flag regulatory-driven moves in the quote
Narrow producer base
Fewer plants make this specific amino-phenol than make bulk anilines, so availability can move faster on a single plant's schedule change.
- We hold a second qualified source where available
- Qualify early rather than at the last minute
- Custom synthesis lead times can run longer
Specification tier
Cosmetic-grade material with a tight colour and related-substance specification prices above a general technical grade. Paying for that assurance is worth it for a formulation dossier; not always necessary for a heterocyclic synthesis route.
- Tell us the end use, not just the purity number
- We will say when a tighter spec is unnecessary
- Cosmetic documentation adds a modest cost
Lot age and freshness
Aged stock on this product is worth less, because colour drift and assay loss from air exposure are real quality signals here, not cosmetic ones.
- Ask for the manufacturing date, always
- Check colour on arrival, not at point of use
- Scheduled release beats bulk stockpiling
Freight & documentation cost
Cosmetic-use shipments sometimes need additional supporting documentation for customs and formulation-dossier purposes, which is worth planning for rather than requesting after the fact.
- Tell us your end use up front
- We quote FOB, CIF, CFR or DDP as you prefer
- Cold-chain transport, where required, carries a premium
Pack format
Cost per kilo falls from bags to drums. If your process can take a larger unit and storage can support it, the saving over a campaign usually outweighs the handling change.
- Small bags carry the highest packing cost
- Cold-chain packing has a modest premium
- Disposal of packing is a hidden cost at your end
| If your end use is… | Specify |
|---|---|
| Hair colourant formulation | Cosmetic-grade colour and purity spec; full documentation |
| Heterocyclic synthesis | High assay; isomer purity confirmed against target |
| Pharmaceutical intermediates | Tight related-substance limit; metals reported |
| Analytical / reference use | Highest available purity, full analytical pack |
| Laboratory / R&D | Small pack, cold-chain packing, fast despatch |
Not sure which column you are in? Describe your end use and our technical desk will recommend the grade and the correct documentation pathway.
Support that goes beyond shipping the drum
What our technical desk will do
- Confirm your end use first. Cosmetic formulation and fine chemical synthesis often call for different documentation, and we ask before we quote.
- Be honest about the hazard profile. We state the IARC Group 2B classification at enquiry stage so your EHS and regulatory teams can factor it into the decision early.
- Advise on cold-chain needs for your specific storage and transit conditions.
- Review your specification before it goes into a contract, so you are not locked into a limit that no plant can consistently hit.
Regulatory & compliance notes
- Cosmetic-ingredient status. Where the end use is a hair colourant, confirm the current regulatory status of this ingredient in your destination market — cosmetic ingredient regulations are reviewed periodically and status can change. We check this before quoting.
- IARC classification. Given the Group 2B classification, confirm your site's occupational health obligations and any downstream labelling requirements before the first delivery.
- Import controls vary by destination. We check the destination rules before quoting, not after you have raised the PO.
- Chemical inventory listings differ between regions. Confirm your obligations under the applicable inventory regime for your import volume — we will supply the identity data you need for that filing.
None of the above is legal advice — your own regulatory affairs team owns the final compliance position for your import and your end use, particularly for cosmetic ingredients, where rules are actively reviewed and can change. What we commit to is giving you accurate product identity data, an honest statement of the hazard classification and complete documentation to work from.
From enquiry to delivered pallet
Tell us your end use
Hair colourant formulation, heterocyclic synthesis, or research — this decides the correct source and documentation before we even discuss price.
Receive a firm quote
Pricing, lead time, packing, regulatory position and Incoterm confirmed in writing within 24 hours — our sourcing desk is staffed around the clock.
Qualify and approve
Sample dispatched if you are qualifying a new source. Batch COA and manufacturing date shared for your approval before the material is released.
Ship and track
Correct classification and documentation filed, freight booked, and the consignment tracked through transit and clearance to your plant.
What buyers ask us about Para Chloro Ortho Amino Phenol
Is this ingredient still permitted in hair colourant formulations?
Is this material carcinogenic?
What purity do you normally supply?
Why does the colour vary from batch to batch?
What is the minimum order quantity?
How long does delivery take?
How should we store it, and what is the shelf life?
What paperwork comes with the consignment?
- Batch certificate of analysis, with the manufacturing date
- Safety data sheet
- Transport documentation appropriate to the confirmed classification
- Commercial invoice, packing list and bill of lading or airway bill
- Certificate of origin and, for cosmetic end uses, supporting identity documentation on request
Do you supply to my country?
Do you manufacture this yourself?
Can you hold stock against a production or formulation plan?
Request pricing on Para Chloro Ortho Amino Phenol
Tell us your end use — hair colourant formulation, heterocyclic synthesis, or research — along with required assay, quantity, pack format and destination port. Our sourcing desk is available 24 hours a day, 7 days a week, and comes back with pricing, lead time, the correct documentation pathway and packing options.