Calcium Pantothenate (Vitamin B5)
Pantothenic acid itself is an oil too unstable to ship or store. The calcium salt solves that: a free-flowing, shelf-stable crystalline powder that carries the same coenzyme-A-precursor chemistry into supplements, infant formula, fortified food and feed premixes.
Chelora Chemicals supplies USP/EP-grade calcium pantothenate to pharma, supplement, food and animal-feed premix manufacturers worldwide, with a batch COA on every consignment.
Product identity
- CAS Number
- 137-08-6
- IUPAC name
- Calcium D-pantothenate
- Molecular formula
- C₁₈H₃₂CaN₂O₁₀
- Molecular weight
- 476.53 g/mol
- EC / EINECS
- 205-278-9
- Hazard classification
- Not classified (GHS)
- Optical rotation
- +25 to +27.5° (c=5, H₂O)
- HS Code
- 2936 24*
* Confirm the current HS classification and food/feed/pharma regulatory status for your destination with your own regulatory affairs team.
What Calcium Pantothenate is used for
Calcium pantothenate is a white, odourless crystalline powder, the calcium salt of D-pantothenic acid (Vitamin B5). Pantothenic acid is the precursor to coenzyme A, central to fatty-acid metabolism and energy production in every cell — but the free acid is a viscous, hygroscopic oil that is impractical to ship, weigh or store. The calcium salt converts that same chemistry into a stable, free-flowing powder, which is why it — not pantothenic acid itself — is the commercial Vitamin B5 raw material.
Its principal markets are dietary supplements and multivitamin blends, infant formula fortification, food and beverage fortification, and animal feed and premix manufacture — four buyer groups drawing on the same specification.
Where it sits among B-vitamin salts
- Calcium pantothenate (this product) the standard, stable commercial form of Vitamin B5.
- Pantothenic acid (free acid) the unstable oil the salt is made from — rarely traded directly.
- Sodium pantothenate an alternative salt used in some low-calcium or liquid formulations, available on request.
- D- versus DL- form only the D-isomer is biologically active; confirm which your specification calls for.
See our wider nutraceutical range for the other B-vitamin intermediates we supply, including niacinamide (Vitamin B3) and folic acid (Vitamin B9).
Appearance and handling character
The material is a mildly hygroscopic, free-flowing powder, freely soluble in water, that should be kept in sealed packing to avoid moisture pickup and caking. It carries no GHS hazard classification and is not regulated as a dangerous good.
| Parameter | Typical value |
|---|---|
| Appearance | White crystalline powder |
| Assay (titration) | 98.0 – 101.0% |
| Melting range | 170 – 172 °C |
| Optical rotation | +25 to +27.5° (c=5, H₂O) |
| pH (10% solution) | 6.8 – 8.0 |
| Calcium content | 8.2 – 8.6% |
| Nitrogen content | 5.7 – 6.0% |
Important: the figures above are indicative of commercial USP/EP-grade material and are offered for planning only. The batch certificate of analysis is the governing document. Confirm the D- versus DL- isomer specification before ordering.
| Property | Value |
|---|---|
| Physical state | Crystalline solid at ambient |
| Water solubility | Freely soluble, >300 g/L at 25 °C |
| Hygroscopicity | Mildly hygroscopic |
| Thermal stability | Stable under normal processing heat; degrades above melting point |
| Stability in acid/alkali | Hydrolyses under strongly acidic or alkaline conditions |
| Light sensitivity | Not significantly light-sensitive |
Physical constants compiled from public reference and pharmacopoeia data for CAS 137-08-6 and rounded for readability. Treat them as orientation, not as a specification.
Where our customers put this vitamin to work
A stable Vitamin B5 raw material that four distinct buyer groups all specify from the same batch.
Dietary supplements
A core B-complex and multivitamin ingredient supplied for tablet, capsule, gummy and powder-blend manufacture.
- USP/EP pharmacopoeia grades
- Compressibility data on request
- Small packs for formulation trials
Infant formula
Used at carefully controlled fortification levels in infant and follow-on formula to meet statutory Vitamin B5 content.
- Infant-formula-grade documentation package
- Heavy-metal and microbiological reporting
- Batch traceability to the producing plant
Food & beverage fortification
Added to functional foods, cereals and fortified beverages to meet guaranteed Vitamin B5 declarations.
- Food-grade documentation
- Compliant with major fortification standards
- Technical desk support on dosing
Animal feed & premix
A standard component of poultry, swine, aquaculture and companion-animal vitamin premixes.
- Feed-grade specification available
- Bulk-bag packing for premix houses
- Contracted annual tonnage supported
Cosmetic & personal-care formulation
Used in some hair and skin-care formulations for its moisturising and conditioning reputation, alongside its related alcohol, panthenol.
- Cosmetic-ingredient grade on request
- INCI-standard documentation supplied
- Ask about panthenol if that is the form you need
Research & analytical use
Reference standard and small-scale formulation trial quantities with the same documentation as the commercial lot.
- Packs from 100 g
- Full analytical documentation available
- Retained sample held against the lot
How we supply Calcium Pantothenate
Chelora Chemicals is a supplier and sourcing partner, not a manufacturer. On a pharmacopoeia-grade vitamin salt, that means we route your order to a producer whose quality system — not just its price list — matches the market you are selling into.
We place your order with whichever qualified producer best matches your target monograph, your price point and your delivery window.
We keep a second qualified source on this line, because calcium pantothenate demand runs year-round across supplement, infant-formula, food and feed customers simultaneously.
- Isomer confirmed before we quote. D- versus DL- form changes biological activity, and we confirm which your specification calls for up front.
- Target monograph confirmed before we quote. USP, EP or feed-grade documentation differ, and we match before pricing.
- Moisture-barrier packing as standard. A specification point on a mildly hygroscopic material, not packaging detail.
- Optical rotation reported on every COA. Our check against the correct D-isomer, not just the raw assay number.
- Batch traceability to the producing plant. Full chain of custody documentation on request.
- Export machinery handled in-house. Classification, labelling, freight booking and customs paperwork are ours to manage.
Packed the way your plant receives it
On a mildly hygroscopic powder, the pack is protecting shelf life as much as containing the product. Tell us your production-line format and we will quote to it.
Fibre drums, moisture-lined
The standard commercial format, with a food/pharma-grade moisture-barrier inner liner to protect the hygroscopic powder.
Multi-wall paper cartons
Lighter, stackable cartons preferred by some supplement manufacturers for warehouse handling.
Bulk bags (FIBC)
For contracted premix-house and fortification-line volumes, moisture-barrier lined as standard.
Trial / sample quantities
Small packs dispatched for formulation or shelf-stability trials before a commercial order is placed.
Incoterms to suit you
Quoted on the Incoterm your purchasing team works to, with documentation filed before the booking is made.
Contracted call-off supply
We hold contracted tonnage and release it against your production calendar, rather than asking you to warehouse it.
A vitamin ingredient with no GHS hazard classification
Calcium pantothenate carries no GHS hazard classification and is not regulated as a dangerous good. The guidance below is good-manufacturing-practice orientation — your facility's own food/pharma handling procedures and the SDS supplied with your consignment remain the governing documents.
Hazard classification
Calcium pantothenate is not classified as hazardous under GHS/CLP for acute toxicity, irritation, sensitisation or environmental endpoints. It is nonetheless handled under standard good-manufacturing-practice housekeeping, since any fine powder deserves dust control regardless of toxicological classification.
General handling notes
Treat it with the same care you would apply to any bulk food or pharmaceutical powder ingredient — plus one extra point specific to this material.
- Minimise open-air exposure time. The mildly hygroscopic powder will pick up moisture and start to cake if left open in humid conditions.
- Routine dust control on transfer. Good practice for any fine powder on a production line.
- Standard food/pharma PPE. Gloves and a dust mask are reasonable good practice during bulk handling and weighing.
- No special spill procedure required. Sweep or vacuum and dispose of as ordinary solid waste, or reclaim if within specification.
Storage
- Cool, dry warehouse storage, sealed. The single most important storage point — moisture ingress is the main shelf-life risk for this material.
- Keep containers tightly closed between uses. Reseal promptly after any partial draw-down.
- Avoid storage near strong acids or alkalis. The amide linkage can hydrolyse under strongly acidic or alkaline conditions.
- Rotate stock on a first-in-first-out basis. Straightforward inventory practice for any vitamin raw material with a defined shelf life.
Handling & PPE
- Standard GMP handling. Treat it as you would any bulk vitamin or nutraceutical powder ingredient in a food, feed or pharma facility.
- Dust mask and gloves during bulk transfer. Reasonable good practice rather than a hazard-driven requirement.
- Reseal packaging promptly. Limits both dust generation and moisture pickup during intermediate storage.
- Food-contact-grade equipment where relevant. Standard requirement for food and infant-formula fortification lines.
Transport
Calcium pantothenate is not regulated as a dangerous good for air, sea or road transport under IATA, IMDG or ADR/RID rules. It ships as ordinary general cargo — ask us for a freight quote alongside your product pricing.
What travels with every consignment
On a vitamin that enters infant formula and dietary supplements, the paper trail is as important as the assay.
Certificate of Analysis
Batch-specific assay, optical rotation, pH, calcium and nitrogen content, heavy metals and microbiological results against your chosen monograph.
Safety Data Sheet
Full-section SDS covering composition, handling, storage and disposal, in the language your destination requires.
Monograph compliance statement
Written confirmation of compliance with the USP or EP monograph you have specified, including optical isomer confirmation.
Non-GMO & allergen statements
Standard declarations requested by food, infant-formula and supplement customers, issued by the producing plant.
Certificate of Origin
Chamber-attested where required, plus preferential-origin forms where a trade agreement gives your import duty relief.
Retained & pre-shipment samples
Pre-shipment samples carry the same COA as the commercial lot, so what your laboratory qualifies is exactly what arrives.
Why a salt form instead of the vitamin itself
Pantothenic acid's own instability is the whole reason calcium pantothenate exists as a trade commodity. The outline below is general background, not a process disclosure.
Build the pantothenate structure
Industrial routes condense D-pantolactone with beta-alanine (or its salt) to form D-pantothenic acid.
Neutralise to the calcium salt
The unstable free acid is immediately converted to its calcium salt, giving the stable, crystallisable commercial form.
Crystallise and purify
The product is crystallised, washed and dried to pharmacopoeia purity under controlled conditions.
Mill and QC release
Particle size is adjusted for the target application and the batch is tested against the specified monograph before release.
Why it matters biologically
Pantothenic acid is the precursor to one of biology's most central cofactors:
- Coenzyme A (CoA). Essential to fatty-acid synthesis and oxidation, and to the citric-acid cycle that powers cellular respiration.
- Acyl carrier protein. Also built from pantothenate, central to fatty-acid chain assembly.
- True dietary deficiency is rare because pantothenic acid is widespread in foods, which is why fortification focuses on guaranteeing a minimum level rather than correcting a common gap.
- Only the D-isomer is biologically active — this is why optical rotation, not just assay, appears on the specification.
That biochemistry is also why documentation matters here — a batch entering infant formula or a pharmacopoeia-grade supplement needs the same rigor as a pharmaceutical active, even though the molecule itself carries no hazard classification.
| Material | Position in the family |
|---|---|
| Calcium pantothenate CAS 137-08-6 — this product | Vitamin B5 (calcium salt) |
| Niacinamide CAS 98-92-0 | Vitamin B3 |
| Folic acid CAS 59-30-3 | Vitamin B9 |
| Vitamin E acetate CAS 7695-91-2 | Fat-soluble antioxidant vitamin |
We supply across this vitamin and nutraceutical range — see the full intermediate range. Send the CAS number and we will confirm the correct material before quoting.
What actually moves the price of this product
Knowing what drives the quote helps you time a purchase and read whether an offer is realistic.
Pantolactone & beta-alanine feedstock
Production depends on these two building blocks, so their fermentation and petrochemical cost bases filter through.
- We flag feedstock-driven moves in the quote
- Longer contracts smooth short-term swings
- Ask about indexed pricing on large volumes
Grade and isomer purity
D-isomer purity and pharmacopoeia-grade documentation cost more than a feed-grade specification of the same nominal assay.
- Tell us the real monograph you need
- We will say when feed grade will do
- Over-specification is the commonest cost leak
Moisture-barrier packing
The hygroscopic nature of this powder makes packing quality a real cost and quality lever, not a cosmetic choice.
- Compare packing cost against spoilage risk
- Ask about moisture-barrier upgrades
- We quote both standard and upgraded packing
Freight and packing format
Non-dangerous-goods status keeps freight simple — bulk bags typically beat drums on a landed-cost basis at volume.
- Compare on landed cost, not ex-works
- Ask about bulk-bag pricing at contracted volumes
- We quote FOB, CIF, CFR or DDP as you prefer
Source geography
Global supply is concentrated among a handful of specialist vitamin producers, so logistics lead time can matter as much as unit price.
- We hold a second qualified source on this line
- Ask which sourcing region best fits your lane
- Regional stock can shorten lead time materially
Shelf life and inventory
A 24-36 month shelf life (sealed) gives flexibility to buy ahead of a forecast price move, provided moisture-barrier packing is maintained.
- Buy to schedule rather than to price alone
- We hold inventory and release on call-off
- Ask about scheduled despatch
| If your end use is… | Specify |
|---|---|
| Dietary supplements / tablets | USP/EP grade, D-isomer confirmed |
| Infant formula | Full documentation package, micro/heavy-metal reporting |
| Food & beverage fortification | Food-grade, standard particle size |
| Animal feed premix | Feed-grade specification |
| Cosmetic / personal-care use | Cosmetic-ingredient grade; ask about panthenol alternative |
Not sure which row you are in? Describe your formulation and our technical desk will recommend the grade and isomer specification.
Support that goes beyond shipping the drum
What our technical desk will do
- Confirm the D-isomer before anything else. Only the D-form is biologically active, and it is the first thing we check against your purchase order.
- Confirm your target monograph. USP, EP or feed-grade documentation each drive different testing and paperwork.
- Recommend packing for your climate and transit. Moisture-barrier upgrades are worth the cost on some routes and unnecessary on others, and we will say which.
- Flag shelf-life risk honestly. If your warehouse conditions are humid, we will say so rather than let a stockpile go off-spec quietly.
Regulatory & compliance notes
- Food and feed additive status varies by country. We check destination rules before quoting, not after you have raised the PO.
- Fortification levels are regulated, not optional. Many jurisdictions set maximum and minimum Vitamin B5 levels in fortified foods and infant formula.
- Pharmacopoeia compliance is batch-specific. We confirm which monograph version a given batch was tested against.
- Cosmetic ingredient listings differ between regions. We supply the identity data you need for your cosmetic-ingredient filing.
None of the above is legal, nutritional or regulatory advice — your own regulatory affairs team owns the final compliance position for your product. What we commit to is accurate product identity data, an honest statement of specification, and complete documentation to work from.
From enquiry to delivered pallet
Send the specification
Product name or CAS 137-08-6, isomer and target monograph, end use, quantity, pack preference and destination port.
Receive a firm quote
Pricing, lead time, packing and Incoterm confirmed in writing within 24 hours — our sourcing desk is staffed around the clock.
Qualify and approve
Sample dispatched if you are qualifying a new source. Batch COA shared for your approval before the material is released.
Ship and track
Documentation issued, freight booked, and the consignment tracked through transit and clearance to your door.
Others in the Chelora range
What buyers ask us about Calcium Pantothenate
What is calcium pantothenate used for?
Why the calcium salt rather than pantothenic acid itself?
What grade do you supply?
Is calcium pantothenate hazardous to handle?
How is it packed and what is the shelf life?
What is the minimum order quantity?
What is the correct CAS number — I have seen more than one?
Do you manufacture this yourself?
Request pricing on Calcium Pantothenate (Vitamin B5)
Send your target monograph, intended end use, quantity, pack format and destination port. Our sourcing desk is available 24 hours a day, 7 days a week, and comes back with pricing, lead time and packing options.