N,N,4-Trimethylaniline
N,N,4-Trimethylaniline — better known in the trade as N,N-dimethyl-p-toluidine (DMPT) — combines the fully alkylated nitrogen of N,N-dimethylaniline with a methyl group on the ring. That third methyl is what makes this compound the accelerator of choice across dental and orthopaedic bone cements, and a long-standing industrial adhesive and dye ingredient.
Chelora Chemicals supplies DMPT to dental and medical-device material manufacturers, adhesive formulators and dye producers worldwide, in drums and bulk quantities, with a batch COA and GHS safety data sheet on every consignment.
Product identity
- CAS Number
- 99-97-8
- IUPAC name
- N,N,4-Trimethylaniline
- Common name
- N,N-Dimethyl-p-toluidine (DMPT)
- Molecular formula
- C9H13N
- Molecular weight
- 135.21 g/mol
- EC / EINECS
- 202-805-4
- MDL number
- MFCD00008316
- SMILES
- CN(C)c1ccc(C)cc1
Note: if your end use is a medical device (dental or orthopaedic cement), we can support the identity and purity documentation your formulation dossier requires — tell us at enquiry stage.
What N,N,4-Trimethylaniline is used for
N,N,4-Trimethylaniline is N,N-dimethylaniline with an additional methyl group installed para to the nitrogen — the compound almost universally known in industry as N,N-dimethyl-p-toluidine, or DMPT. That extra ring methyl has an outsized practical effect: it is the single most widely used tertiary-amine accelerator for the room-temperature, peroxide-initiated cure of methacrylate resins, a role it has held in dental restorative materials, bone cements and structural adhesives for decades.
In dental and orthopaedic bone cement systems, DMPT is combined with a peroxide initiator — usually benzoyl peroxide — at concentrations typically between 0.5% and 3%. The amine reduces the peroxide to generate free radicals, initiating the polymerisation of methyl methacrylate monomer at body or room temperature without external heating. It has served this role in acrylic denture material manufacture for roughly fifty years. Beyond that, DMPT is a component of certain industrial glues and artificial fingernail preparations where fast, room-temperature setting is needed, and an intermediate in dye and pesticide synthesis.
Why the extra methyl matters
DMPT is closely related to but functionally distinct from the plain dimethylaniline it is built from:
- N,N,4-Trimethylaniline / DMPT (CAS 99-97-8) — this product. The ring methyl para to the amine gives it the specific reactivity profile that has made it the standard accelerator in acrylic bone cement and dental chemistry.
- N,N-Dimethylaniline (CAS 121-69-7) — the parent compound without the ring methyl, used more in dye synthesis than as an accelerator, though it can serve a similar function in some formulations.
- N,N-Diethylaniline (CAS 91-66-7) — a different tertiary amine entirely, used mainly in dye and rubber chemistry.
If your formulation specification calls for DMPT specifically, confirm the CAS number — 99-97-8 — on your purchase order. We supply the related N-alkylaniline range as well; see the full intermediate range.
Appearance and handling character
DMPT ships as a colourless to light yellow clear liquid with a melting point in the region of -15 to -25 °C, so it is a liquid through virtually any ambient storage or transport condition. It is essentially insoluble in water and soluble in ether, alcohol and chloroform. Like other aromatic amines it is air-sensitive and darkens with age; suppliers commonly recommend cool, dark storage under inert gas. It carries a carcinogenicity classification (H350) in published hazard data, which should shape every handling decision from the outset.
| Parameter | Typical value |
|---|---|
| Appearance | Colourless to light yellow clear liquid |
| Assay (GC) | 98.0% min |
| Moisture | Reported per batch |
| Colour (APHA) | Reported per batch — critical for medical-device grades |
| Residual p-toluidine | Reported per batch |
| Peroxide value | Reported per batch on request |
Important: the figures above are indicative of commercial grade material and are offered for planning only. The batch certificate of analysis is the governing document. Medical-device buyers typically specify a tighter colour and purity envelope than a general technical grade — send us your specification and we will source to it.
| Property | Value |
|---|---|
| Physical state | Liquid at ambient |
| Melting point | ≈ -15 to -25 °C |
| Boiling point | ≈ 210 – 215 °C @ 760 mmHg |
| Flash point | ≈ 76 – 83 °C |
| Relative density | ≈ 0.93 – 0.94 |
| Water solubility | ≈ 0.35 – 0.65 g/L — sparingly soluble |
| Organic solubility | Soluble in ether, alcohol, chloroform |
Physical constants compiled from public reference data for CAS 99-97-8 and rounded for readability. Treat them as orientation, not as a specification.
Where our customers put this molecule to work
DMPT's dominant use is as a cure accelerator in acrylic medical and dental materials, with secondary use across industrial adhesives, dyes and pesticide synthesis.
Dental & orthopaedic bone cement accelerator
DMPT is the standard tertiary-amine accelerator for peroxide-cured PMMA-based systems, used in dental restorative materials, denture base resin and acrylic bone cement for joint replacement fixation — a role it has held for roughly five decades.
- Typical formulation level 0.5–3%
- Colour and purity critical for medical-device grade
- We support formulation-dossier documentation
Industrial adhesives & glues
The same room-temperature redox-cure chemistry that makes DMPT useful in dental materials makes it valuable in industrial acrylic adhesives and glues where fast setting without external heat is required.
- Structural and specialty adhesive formulation
- Redox accelerator with peroxide initiators
- Trace-level formulation ingredient
Artificial fingernail preparations
DMPT's accelerator role extends to acrylic artificial fingernail systems, where the same peroxide-amine redox chemistry drives the fast cure that the cosmetic application requires.
- Cosmetic acrylic system accelerator
- Trace-level formulation ingredient
- Documentation support available on request
Dye & pesticide intermediates
Beyond its accelerator role, DMPT is used as an intermediate in dye synthesis and in certain pesticide manufacturing routes, drawing on the same strongly activated aromatic ring.
- Dye intermediate chemistry
- Pesticide synthesis intermediate
- See our dye and agrochemical ranges
Research & analytical use
DMPT is used in some analytical and biochemical research applications, and as a reference standard for method development in laboratories working with N-alkylaniline chemistry.
- Reference and analytical quantities
- Small pack sizes available
- Full analytical documentation available
Contract & scheduled supply
Medical-device and adhesive formulators run to production campaign. We hold inventory and release it against your production plan rather than in one shipment.
- Annual contracts with scheduled call-off
- Price held across the contract period
- Second source held in reserve
How we supply DMPT
Chelora Chemicals is a supplier and sourcing partner, not a manufacturer. We own no aniline-alkylation plant — and for a compound used in medical-device formulation, where colour, purity and source traceability all matter, that independence lets us route your order to a producer that can actually support your dossier requirements.
We place your order with whichever qualified producer best matches your assay, your colour requirement, your documentation needs and your delivery window.
We keep a second qualified source on this line. When a plant goes down for maintenance, your campaign switches source rather than stalling.
- Specification read against the CAS first. We confirm you need 99-97-8 (DMPT) and not the plain dimethylaniline or a diethyl relative before we quote a price.
- Batch COA shared before dispatch. You approve the assay, colour and impurity profile against your own spec while the material is still in our warehouse.
- Hazard status stated up front. This material carries a carcinogenicity classification, and we say so at enquiry stage — not in the small print of a document pack that arrives with the goods.
- Medical-device documentation support. Where DMPT feeds a dental or orthopaedic cement formulation, we work with you on the identity and purity documentation your dossier requires.
- Pre-shipment samples for qualification. New account or new source, your laboratory runs a cure trial before the full quantity ever moves.
- Export machinery handled in-house. Hazard classification, UN-approved packing, labelling, freight booking and customs paperwork are ours to manage.
Packed the way your plant receives it
Colour and purity retention matter for medical-device grades. Tell us your end use and destination climate and we will quote the format that protects the material in transit.
MS / HDPE-lined drums
UN-certified drums for liquid product, with inert-gas headspace available on request for medical-device grades where colour retention matters.
IBC totes / flexitanks
Intermediate bulk containers or flexitank liners for full-container liquid loads, reducing packing cost per litre for high-volume users.
Nitrogen-blanketed drums
For medical-device and dye-grade buyers where colour ceiling matters most, nitrogen-blanketed drum packing limits oxidative colour drift in transit.
Samples & trial packs
Laboratory samples and pilot quantities dispatched by courier so your formulation laboratory can run a cure trial before committing to campaign volume.
Incoterms to suit you
Quoted on the Incoterm your purchasing team works to. Ocean, air and road freight arranged end-to-end with documentation filed before booking.
Campaign despatch
Medical-device manufacturing runs to production plan. We hold contracted tonnage and release it against your calendar instead of landing it all at once.
Handle this as a classified carcinogen and sensitiser
DMPT commonly carries a carcinogenicity classification (H350) in published GHS data, alongside a suspected-fertility-damage entry, skin sensitisation and acute toxicity by ingestion and skin contact. This material demands the same rigour in the plant as it does in dental clinics, where trace-level exposure has been studied for decades. The summary below is orientation only — the safety data sheet supplied with your consignment is the authoritative document and should govern your risk assessment, PPE selection, exposure monitoring and emergency planning.
Classified hazards
H301+H311Toxic if swallowed or in contact with skin.H317May cause an allergic skin reaction.H332Harmful if inhaled.H350May cause cancer.H361fSuspected of damaging fertility.H373May cause organ damage through prolonged or repeated exposure.H412Harmful to aquatic life with long lasting effects.
Hazard statements reflect the GHS classification commonly published for CAS 99-97-8. Always read the SDS issued with your specific batch, and treat the carcinogenicity and skin-sensitisation entries as the ones that should shape your controls most, especially for personnel handling this material regularly.
Spill & emergency orientation
Plan your response before the drum arrives, not after a valve leaks. The points below are orientation for your emergency planners — sections 4, 5 and 6 of the SDS are the authoritative instructions and should be posted at the point of use.
- Contain, do not hose to drain. The material is harmful to aquatic life. Contain the liquid with absorbent material and collect it into a labelled container.
- Avoid ignition sources. Conditions to avoid include electrical spark, open flame and exposure to air — keep the area free of ignition sources during a spill response.
- Assume skin absorption and sensitisation risk. Contaminated clothing is a continuing exposure route — remove it immediately and wash the skin thoroughly. Repeat contact raises the risk of an allergic skin reaction.
- Have the SDS with the casualty. The treating clinician needs the product identity, CAS number and hazard classification in hand.
- Record the exposure. With a carcinogenicity classification, most occupational regimes expect an exposure record to be created and retained — a decision for your EHS function, made easier before an incident than after one.
Storage
- Cool, dark, sealed storage, ideally under inert gas — this compound is genuinely air-sensitive and conditions to avoid include exposure to air, electrical spark and open flame.
- Access-controlled storage. Given the carcinogenicity classification, restricting who can reach the store is a control measure, not an administrative nicety.
- Segregate from oxidising agents and other incompatible materials per the SDS.
- Keep containers tightly closed between uses rather than leaving a drum open across a shift.
- Shelf life is typically 12–24 months in sealed original packing under recommended storage conditions.
Handling & PPE
- Design exposure out where practical. Closed transfer and mechanical charging reduce both acute exposure and any long-term concern associated with the carcinogenicity classification.
- Skin protection is the priority, given the sensitisation entry — chemical-resistant gloves and coveralls, not just splash protection, and a strict no-bare-skin-contact rule.
- Respiratory protection where vapour or mist concentrations may exceed exposure limits, per your exposure assessment.
- Eye protection and an accessible, tested eyewash and safety shower at every charging point.
- Health surveillance is worth discussing with your occupational health provider given the carcinogenicity and fertility-damage classifications, particularly for regular handlers.
Transport
DMPT moves as regulated cargo (UN 1708). We classify each consignment, apply UN-approved packaging and labelling, and file the dangerous-goods declaration before the booking is made. The applicable class and packing group are stated on your shipping documents and SDS — ask us for the current DG paperwork when you plan the shipment.
What travels with every consignment
A chemical shipment is only as good as the file that travels with it. Verifying what the source plant sends is precisely the work you are buying from a supplier.
Certificate of Analysis
Batch-specific assay, appearance, colour and impurity profile — checked against your purchase specification before we release the goods.
Manufacturing date & lot age
For an air-sensitive tertiary amine this belongs on the same page as the assay. We disclose production date and storage history for the lot we are offering.
GHS Safety Data Sheet
Full 16-section SDS covering hazards, exposure controls, handling, storage, spill response and disposal — issued in the language your destination requires.
Dangerous Goods Declaration
UN 1708 number, hazard class, packing group and IMDG or IATA declaration prepared and filed before the container is booked, with correctly marked and labelled packaging.
Medical-device documentation
For dental and orthopaedic cement end uses, we can support the identity and purity documentation your formulation dossier requires, subject to your destination's regulatory framework.
Retained & pre-shipment samples
Pre-shipment samples carry the same COA as the commercial lot, so what your laboratory qualifies is exactly what arrives. Retention samples held against the batch.
How a tertiary amine starts a polymerisation
Understanding DMPT's redox role explains why colour and purity matter as much as raw assay in this application. The notes below are general background, not a formulation disclosure.
Two components meet
DMPT and a peroxide initiator — typically benzoyl peroxide — are combined in a two-part methacrylate resin system, kept apart until use.
The amine reduces the peroxide
On mixing, the tertiary amine nitrogen donates an electron to the peroxide, cleaving it homolytically and generating free radicals without any external heat input.
Radicals drive the cure
The radicals initiate chain-growth polymerisation of methyl methacrylate monomer, curing the resin at ambient or body temperature within minutes.
Trace level, outsized effect
Typical use levels of 0.5–3% are enough to drive a complete, controllable cure — which is why colour and purity consistency in the DMPT itself directly affects cure speed and reliability.
Why feed quality carries through the whole route
Because DMPT acts catalytically at a trace level, small variations in its purity have a disproportionate effect on the finished cure:
- Colour drift from oxidation is not just cosmetic here — oxidised amine species have reduced reducing power and can slow or make cure timing inconsistent.
- Residual p-toluidine from incomplete methylation reacts differently in the redox step and can affect cure kinetics and colour of the finished product.
- Moisture content can interfere with the dissolved-phase chemistry of a two-part resin system.
- Trace metal contamination can independently catalyse or inhibit the peroxide decomposition step, confounding formulation troubleshooting.
That chain of consequences is the reason we quote against your written specification rather than a generic grade, and the reason the batch COA and lot age are both shared for approval before dispatch.
| Intermediate | Principal outlet |
|---|---|
| DMPT CAS 99-97-8 — this product | Dental & bone cement accelerator Industrial adhesives, dyes |
| N,N-Dimethylaniline CAS 121-69-7 | Dye chemistry Occasional accelerator role |
| N,N-Diethylaniline CAS 91-66-7 | Dye & rubber chemistry Different tertiary amine |
We supply the related N-alkylaniline range as well — see the full intermediate range. Send the CAS number and we will confirm the correct material before quoting.
What actually moves the price of this intermediate
DMPT is not a commodity with a screen price. Knowing what drives the quote helps you time a purchase and read whether an offer is realistic.
Medical-device demand is steady
Dental and orthopaedic cement production runs at a fairly consistent pace year-round, which tends to make DMPT demand steadier than a seasonal agrochemical intermediate.
- Contracted call-off smooths routine demand
- Medical-device qualification favours source continuity
- We flag any supply disruption early
Upstream feedstock
The route back to DMPT runs through p-toluidine and methylation chemistry. Movements in toluene, ammonia and methanol feed through within a quarter or so.
- p-Toluidine and methylation reagent cost set the floor
- Energy cost weighs on distillation
- We flag feedstock-driven moves in the quote
Medical-device grade premium
Material with the colour ceiling and purity consistency a medical-device dossier demands prices above a general technical grade. That is usually money well spent, given what an inconsistent cure would cost a formulator.
- Tell us the end use, not just the purity number
- We will say when a tighter spec is unnecessary
- Source continuity matters for dossier stability
Lot age and freshness
Aged stock on this product is worth less, because colour drift from air exposure is a genuine functional concern here, not a cosmetic one.
- Ask for the manufacturing date, always
- Check colour on arrival, not at point of use
- Scheduled release beats bulk stockpiling
Freight & DG surcharges
This is regulated cargo, so freight carries a hazardous surcharge and space is tighter than for general cargo. Destination and Incoterm move landed cost as much as the ex-works price does.
- Compare on landed cost, not ex-works
- DG space books out ahead of peak season
- We quote FOB, CIF, CFR or DDP as you prefer
Source availability
A plant turnaround, an environmental inspection or a monsoon disruption can take capacity offline at short notice — and for a medical-device input, re-qualifying a new source takes time.
- We hold a second qualified source on this line
- Qualify the alternate before you need it
- Ask us about dual-source contracts
| If your end use is… | Specify |
|---|---|
| Dental / bone cement | Tight colour ceiling, full formulation-dossier documentation |
| Industrial adhesives | Consistent assay, controlled moisture |
| Dye / pesticide intermediates | High assay; colour ceiling on dye routes |
| Laboratory / R&D | Small pack, inert packing, fast despatch |
Not sure which column you are in? Describe your formulation and our technical desk will recommend the grade and the correct documentation pathway.
Support that goes beyond shipping the drum
What our technical desk will do
- Confirm you need DMPT specifically. We check the CAS number against the plain dimethylaniline or diethyl relatives before quoting, since formulations often specify one precisely.
- Be honest about the hazard profile. We state the carcinogenicity classification at enquiry stage so your EHS and regulatory teams can factor it into the decision early.
- Support medical-device documentation for your specific dossier requirements.
- Review your specification before it goes into a contract, so you are not locked into a limit that no plant can consistently hit.
Regulatory & compliance notes
- Medical-device supplier qualification. Where DMPT feeds a dental or orthopaedic cement, your quality system will likely require supplier qualification and change-control documentation. We support this process.
- Carcinogenicity obligations. Given the H350 classification, confirm your site's occupational health obligations, exposure monitoring and record-retention requirements before the first delivery.
- Import controls vary by destination. We check the destination rules before quoting, not after you have raised the PO.
- Chemical inventory listings differ between regions. Confirm your obligations under the applicable inventory regime for your import volume — we will supply the identity data you need for that filing.
None of the above is legal advice — your own regulatory affairs team owns the final compliance position for your import, your workplace and your medical-device dossier. What we commit to is giving you accurate product identity data, an honest statement of the hazard classification and complete documentation to work from.
From enquiry to delivered drum
Send the specification
Product name or CAS 99-97-8, the assay and colour limits you work to, quantity, pack preference and destination port.
Receive a firm quote
Pricing, lead time, packing, lot age and Incoterm confirmed in writing within 24 hours — our sourcing desk is staffed around the clock.
Qualify and approve
Sample dispatched if you are qualifying a new source. Batch COA and manufacturing date shared for your approval before the material is released.
Ship and track
DG classification filed, freight booked, export documents issued, and the consignment tracked through transit and clearance to your plant.
What buyers ask us about N,N,4-Trimethylaniline (DMPT)
Is this the same as N,N-dimethyl-p-toluidine?
Is this material classified as a carcinogen?
What purity do you normally supply?
Can you support our medical-device supplier qualification?
What is the minimum order quantity?
How long does delivery take?
Why does colour matter so much for this product?
How should we store it, and what is the shelf life?
Is this a dangerous good? What paperwork comes with it?
- Batch certificate of analysis, with the manufacturing date
- GHS-format safety data sheet
- Dangerous-goods declaration with UN number, class and packing group
- Commercial invoice, packing list and bill of lading or airway bill
- Certificate of origin and, where relevant, supporting identity documentation for your formulation dossier
Do you supply to my country?
Do you manufacture this yourself?
Request pricing on N,N,4-Trimethylaniline (DMPT)
Send your required assay, colour ceiling, quantity, pack format and destination port. Our sourcing desk is available 24 hours a day, 7 days a week, and comes back with pricing, lead time, lot age and packing options — whether that is a single trial pack or a contracted programme for the year.